摘要
目的探讨40~65岁女性发生绝经后骨质疏松症骨折的危险因素及中医症状的相关性。方法本研究采用登记式注册研究的方法,课题组于2009年3—8月在北京市东城区及上海市徐汇区收集的1 823例40~65岁女性骨质疏松症高危人群的危险因素及中医症状信息,进行连续3年的登记观察。同时采用Cox比例风险模型的方法,进行单因素、多因素分析,筛选与绝经后骨质疏松症骨折有关的危险因素及中医症状。结果截止到2011年12月共跟踪收集共有1 498条骨折信息,总应答率为82.17%,其中有52例发生了骨质疏松性骨折。以发生绝经后骨质疏松症骨折的时间为结局变量,Cox单因素分析中,平均年龄(RR=1.083,P=0.003)、是否绝经(RR=5.462,P=0.004)、平均绝经年限(RR=1.060,P=0.010)、绝经年限≤10年(RR=4.890,P=0.008)、绝经年限>10年(RR=7.720,P=0.001)、生产次数≥3次(RR=5.870,P=0.003)、目眩(RR=3.037,P=0.001)、下肢拘挛(RR=2.315,P=0.003)及骨密度诊断为骨量减少(RR=2.376,P=0.008)、骨密度诊断为骨质疏松(RR=2.801,P=0.013)的回归参数β大于0,且RR值大于1,提示为绝经后骨质疏松症骨折的致病的危险因素。将骨密度测定诊断、年龄、绝经年限、生产次数、目眩、下肢拘挛6个因素进行Cox多因素分析,绝经年限<10年(RR=3.257,P=0.032)及有目眩(RR=2.655,P=0.005)为其相关变量。结论 "目眩"及"绝经年限"是骨质疏松性骨折的最重要的危险因素,其中"目眩"可能早期预测骨质疏松性骨折的发生。
Objective To observe the correlation between risk factors and symptoms of Chinese medicine （CM） in postmenopausal osteoporosis （OP） of females aged between 40 and 65. Methods Registry method was used in this study. Risk factors and information on symptoms of CM collected from 1 823 OP high risk females （40 -65 years old） in Dongcheng District of Beijing and Xuhui District of Shanghai （collected in our previous research）. Meanwhile, Cox proportional hazard model was also a- dopted to conduct single-factor and multiple-factor analyses. Risk factors and symptoms of CM were screened and analyzed. Results A total of 1 498 subjects attended follow-up surveys, with the response rate of 82.17%. Of them, 52 had brittle fracture. In Cox single-factor analysis, when taking the time foroccurrence of postmenopausal OP as the outcome variable, average age （RR =1.083,P =0.003）, whether menopause （RR = 5.462, P = 0. 004）, average menopausal year （RR = 1. 060, P = 0.010）, menopausal year 〈10 years （RR =4.890,P=0.008）, menopausal year 〉10 year （RR =7.720,P = 0. 001 ）, delivery times 1〉3 times （RR =5.870, P =0.003）, dizziness （RR =3. 037, P =0.001）, spasm of lower limbs （RR =2. 315, P =0.003）, reduced bone mass in bone mass density （BMD） diagnosis （RR = 2. 376, P =0.008）,P 〉0 and RR 〉1 in BMD diagnosis （RR =2.801 ,P =0.013） indicated they were risk factors for postmenopausal OP fracture. When taking BMD diagnosis, age, menopausal year, delivery times, dizziness, and spasm of lower limbs in multiple-factor analysis, menopausal year 〈10 years （RR =3.257 ,P =0.032） and dizziness （RR =2.655,P =0.005） were associated variables. Conclusion Dizzi- ness and menopausal years were most important factors of OP fracture, and dizziness could be taken as symptoms of CM in early predicting occurrence of OP fracture.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2017年第1期50-56,共7页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金面上项目(No.81373885)
北京市中医院科技发展资金资助项目(No.JJ2015-57)
北京市中医药管理局青年基金资助项目(No.QN2016-02)
关键词
绝经后骨质疏松症骨折
危险因素
中医症状
相关性研究
postmenopausal osteoporosis fracture
risk factor
symptoms of Chinese medicine
correlation study
