摘要
有数千种人类疾病与基因突变有关,治疗基因突变的新型有效方法是基因治疗,而高效、低毒、靶向的基因载体是治疗成功的关键。与病毒载体相比,非病毒载体中高分子纳米材料除了相对毒性低、转载量大外,还具有储存稳定、结构灵活、合成和形状易控制等优势,因而成为研究热点之一。我们对高分子材料的纳米基因载体种类、性质和表面修饰等研究进展做简要综述。
There are thousands of diseases associated with genetic mutation in humans. Gene therapy is thenew effective method. High efficiency and low toxic, targeting of gene carrier are the keys to the success of treat-ment. Compared with viral vector, besides lower toxicity, reproduced large amount, non viral vector of polymer na-no materials also has storage stability, flexible structure, synthesis and shape control and so on become one of hotresearch spots. In this paper, the main kinds of polymer materials of nano gene carrier, the properties and surfacemodification on the research progress of gene therapy were reviewed.
出处
《生物技术通讯》
CAS
2016年第6期864-869,共6页
Letters in Biotechnology
基金
江西省青年科学基金(20151BAB215048)
江西科技师范大学第十届本科生科研基金
关键词
高分子材料
基因载体
表面修饰
polymer material
gene vector
surface modification
