摘要
目的探究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对急性缺血性脑卒中患者认知功能及生活质量的影响。方法选取首都医科大学石景山教学医院2014年6月—2016年6月收治的急性缺血性脑卒中并OSAHS患者39例作为试验组,未合并OSAHS的急性缺血性脑卒中患者39例作为对照组。比较两组患者血管内皮细胞功能指标〔包括一氧化氮(NO)、α-颗粒膜蛋白(GMP-140)、血管性假血友病因子(v WF)、内皮素1(ET-1)〕、认知功能评分〔包括简易智能精神状态检查量表(MMSE)、顺背测试、连线测试B及韦氏智力量表中的词汇测试和数字符号测试评分〕及生活质量评分。结果试验组患者血清NO水平低于对照组,血清GMP-140、v WF、ET-1水平高于对照组(P<0.05)。试验组患者MMSE、顺背测试、连线测试B、词汇测试及数字符号测试评分低于对照组(P<0.05)。试验组患者躯体功能、角色功能、情绪功能、认知功能、社会功能及总体健康状况评分低于对照组(P<0.05)。结论 OSAHS可对急性缺血性卒中患者的血管内皮细胞功能、认知功能及生活质量造成不良影响,临床应加以重视和控制。
Objective To explore the impact of obstructive sleep apnea hypopnea syndrome （OSAHS） on cognitive function and quality of life of patients with acute ischemic stroke. Methods From June 2014 to June 2016 in Shijingshan Teaching Hospital of Capital Medical UniVersity, a total of 39 acute ischemic stroke patients complicate with OSAHS were selected as test group, 39 acute ischemic stroke patients did not complicate with OSAHS were selected as control group. Index of vascular endothelial cell function （including NO, GMP-140, vWF and ET-1 ）, MMSE score, Forward Recitation Test score, Trail Making Test B score, Vocabulary Test score and Digit Symbol Test score of Wechsler Intelligence Scale, and quality of life score were compared between the two groups. Results Serum NO level of test group was statistically significantly lower than that of control group, while serum levels of GMP-140, vWF and ET-1 of test group were statistically significantly higher than those of control group （ P 〈 0. 05）. MMSE score, Forward Recitation Test score, Trail Making Test B score, Vocabulary Test score and Digit Symbol Test score of Wechsler Intelligence Scale of test group were statistically significantly lower than those of control group （P 〈 0.05 ）. Physical function score, role function score, emotive function score, cognitive function score, social function score and general health score of test group were statistically significantly lower than those of control group （ P 〈 0. 05 ）. Conclusion OSAHS can induce adverse effects on vascular endothelial cell function, cognitive function and quality of life of patients with acute ischemic stroke, which should be pay more attention to and effectively control. [
出处
《实用心脑肺血管病杂志》
2016年第11期29-31,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
