摘要
目的探究依降钙素联合阿法骨化醇对行内固定手术的肱骨干骨折患者临床效果、腰椎骨密度及安全性的影响。方法选取2010年6月-2016年6月于寻乌县人民医院选择内固定手术治疗的肱骨干骨折患者80例,随机分为对照组和观察组,各40例。对照组术后给予碳酸钙D3片和功能锻炼治疗,观察组在对照组基础上行依降钙素和阿法骨化醇联合治疗,分析并对比2组临床效果、腰椎骨密度及安全性情况。结果与治疗前比较,2组治疗2、3 w血清钙水平显著升高（P〈0.05）;对照组治疗12 w腰椎骨密度显著升高（P〈0.05）,观察组治疗4、12 w腰椎骨密度显著升高（P〈0.05）。与对照组比较,观察组治疗2、3 w血清钙水平较高（P〈0.05）;治疗4、12 w腰椎骨密度较高（P〈0.05）。观察组和对照组治疗后总不良反应率分别为10.00%和15.00%,差异无统计学意义。结论依降钙素和阿法骨化醇联合治疗内固定手术的肱骨干骨折患者效果显著,能够改善患者血清钙水平,促进腰椎骨密度提高,且不良反应较少。
Objective To analyze the effect of calcitonin combined with alfacalcidol on clinical outcome,lumbar vertebrae bone mineral density and safety in patients undergoing internal fixation of humeral shaft fracture. Methods 80 patients with humeral shaft fracture treated with internal fixation in Xunwu county people＇s hospital from June 2010 to June 2016 were selected,and randomly divided into control group and observation group,40 cases in each groups. The control group was given calcium carbonate D3 tablets and functional exercise therapy,the observation group treated calcitonin combined with alfacalcidol on the basis of control group,analysis and comparison the clinical effects,lumbar spine BMD and safety. Results Compared with before treatment,serum calcium level of two groups increased significantly at treatment 2 weeks and 3 weeks（P〈0. 05）; The control group BMD of lumbar spine was significantly increased in treatment 12 weeks（P〈0. 05）,the observation group BMD of lumbar spine was significantly increased in treatment 4 weeks and 12 weeks（P〈0. 05）. Compared with control group,the level of serum calcium in observation group was higher at treatment 2 weeks and 3 weeks（P〈0. 05）,BMD of lumbar spine was higher at treatment 4 weeks and 12 weeks（P〈0. 05）; The total adverse reaction rate of observation group was10%,the difference was not statistically significant to control group 15%. Conclusion The combination of calcitonin and alfacalcidol treatment of internal fixation of humeral shaft fractures in patients with significant results,can improve serum calcium levels in patients with and improve bone mineral density,and less adverse reactions.
出处
《中国生化药物杂志》
CAS
2016年第9期72-73,77,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
肱骨干骨折
内固定术
阿法骨化醇
依降钙素
腰椎骨密度
humeral shaft fracture
internal fixation
alfacalcidol
calcitonin
lumbar spine bone density
