摘要
目的 探讨早期高压氧治疗对血管性痴呆患者高级脑功能及炎症因子的影响.方法 选取2014年6月至2015年12月收治的血管性痴呆患者82例为研究对象,采用随机数表法分为观察组和对照组,每组41例,对照组给予舒血宁注射液,并结合患者血压与血糖情况给予相应控压与降糖措施,观察组在此基础上加用高压氧治疗.均治疗2周,比较两组治疗前后认知功能、平衡功能、肢体运动功能,同时分析患者血清中C-反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-γ（TF-y）水平.结果 观察组LOTCA评分[（100.23±5.38）分]、BBS评分[（49.36±2.07）分]、Fugl-Meyer评分[（90.38±2.51）分]明显高于对照组（P〈0.05）;观察组CRP[（2.43±1.34）mg/L]、IL-6[（19.41±4.23） ng/L]、TNF-γ[（111.45±4.72） ng/L]水平显著低于对照组（P〈0.05）.结论 早期高压氧治疗可有效改善血管性痴呆患者高级脑功能,同时对患者血清中炎症因子的控制有积极影响,值得在临床广泛应用.
Objective To investigate the effect of hyperbaric oxygen therapy on advanced brain function and inflammatory factors in patients with vascular dementia.Methods Eighty-two patients with vascular dementia from June 2014 to December 2015 were selected as the study objects.According to the random number table method,the patients were divided into observation group and the control group,with 41 cases in each group.The control group was treated with Shuxuening injection and was given corresponding pressure control and blood glucose-lowering measures according to the condition of patients＆#39; blood pressure and blood glucose.Based on this,the observation group was treated with hyperbaric oxygen.Both of the two groups were treated for 2 weeks.The cognitive function,balance function and motor function were compared between the two groups before and after treatment.Meanwhile,serum C reaction protein （CRP）,interleukin-6 （IL-6） and tumor necrosis factor gamma （TNF-γ） levels were analyzed.Results LOTCA score （100.23 ±5.38）,BBS score （49.36 ±2.07） and Fugl-Meyer score （90.38 ± 2.51） of the observation group were significantly higher than those of the control group （P 〈 0.05）.The levels of CRP [（2.43 ± 1.34） mg/L],IL-6 [（19.41 ± 4.23） ng/L] and TNF-γ [（111.45-±4.72） ng/L] in the observation group were significantly lower than those in the control group （P 〈 0.05）.Conclusions Early hyperbaric oxygen therapy can effectively improve the advanced brain function of patients with vascular dementia,and have positive effect on the control of serum inflammatory factors.It is worthy of wide use in clinics.
出处
《中国实用医刊》
2016年第19期50-52,共3页
Chinese Journal of Practical Medicine
关键词
早期
高压氧治疗
血管性痴呆
高级脑功能
炎症因子
Early
Hyperbaric oxygen therapy
Vascular dementia
Advanced brain function
Inflammatory factors
