摘要
目的探讨急性脑梗死后发生认知功能障碍的相关因素。方法选择2013年1月至2015年12月南通市第三人民医院诊治的190例急性脑梗死患者作为研究对象，根据是否发生认知功能障碍分为认知功能障碍组和无认知功能障碍组，统计急性脑梗死后认知功能障碍的发生率，对影响急性脑梗死后认知功能障碍的因素（性别、年龄、文化程度、经济状况、婚姻状态、基础疾病、职业、脑血管疾病史、社会支持、神经功能缺损评分、肺部感染、甲状腺功能等）进行单因素分析，并进一步行多因素的Logistic回归分析。结果认知功能障碍的发生率为36．84％（70／190），认知功能障碍组患者中男性、年龄〉70岁、文化程度程度低、经济状况差、其他婚姻状态、合并基础疾病、体力劳动、有脑血管疾病史、缺少社会支持、神经功能缺损〉10分、合并肺部感染、颈动脉斑块形成、脑梗死位置左半球、甲状腺功能减退及亚临床甲状腺功能减退的比例高于无认知功能障碍组（P〈0．05）。Logistic回归分析显示，基础疾病多（OR=4．22，95％CI1．11～22．23）、教育水平低（OR：3．80，95％酣1．30～19．34）、有脑血管疾病史（OR=3．33，95％C10．78—17．34）、存在甲状腺功能减退或亚临床甲状腺功能减退（OR=2．86，95％C11．09～19．80）是急性脑梗死后发生认知功能障碍的危险因素。结论基础疾病多、教育水平低、有脑血管疾病史、存在甲状腺功能减退或亚临床甲状腺功能减退是影响急性脑梗死后认知功能障碍发生的危险因素，积极干预危险因素可减少急性脑梗死后认知功能障碍的发生。
Objective To investigate the-risk factors of cognitive impairment after acute cerebral infarction. Methods From Jan. 2013 to Dec. 2015,190 acute cerebral infarction patients in Nantong Third People＇s Hospital were collected as the research objects, according to cognitive impairment, the patients were divided into a cognitive impairment group, and a non-cognitive impairment group. The incidence of the cogni- tive impairment was calculated, the related factors of cognitive impairment after acutev cerebral infarction （ gender, age, cultural degree, economic status, marital status, basic diseases, occupation, cerebrovaseular disease history, social support, neurologic impairment score, pulmonary infection, carotid plaque, cerebral infarction location,pothyroidism and subclinical hypothyroidism） were analyzed by univariate and multivari- ate Logistic regression analysis. Results The incidence of cognitive impairment was 36.84% （70/190）. The number of male, .age 〉 70 years old, lower cultural degree, poor economic status, other marital status, with basic diseases, manual workers, with cerebrovaseular disease history,lack of social support, neurologic impair- diseases （ OR= 4. 22 ;95 % CI 1.11-22.23 ） ,low education level（ OR = 3.80,95 % CI 1.30-19.34 ）, cerebral vascular disease history （ O,R = 3.33,95 % CI 0. 78-17.34 ）, hypothyroidism and subclinical hypothyroidism （OR =2.86,95%：CI 1.09-19. 80） wen the risk factors of cognitive impairment after acute cerebral infare- tionl Conclusion The increase of basic diseases, low education level, cerebral vascular disease history, hypothyroidism and subclinical hypothyroidism are the risk factors for cognitive impairment after acute cere- bral infarction, so active intervention to the risk factors can reduce the incidence.
出处
《医学综述》
2016年第21期4316-4318,共3页
Medical Recapitulate
