摘要
血清14-3-3η蛋白是新近发现的参与类风湿关节炎(RA)发病机制的促炎介质,其和环瓜氨酸化14-3-3η蛋白及自身抗体是对RA诊断具有高度特异性和敏感性的标志物。它在RA活动性炎症滑膜及血清中表达丰富,与其发病机制、病情活动度、严重性、影像学进展呈正相关,也是治疗反应和预后的负向预测因素。因此,采用诊断灵敏度、特异度、阳性预测值及阴性预测值等指标评价14-3-3η蛋白对RA的诊断效用及其与目前临床、血清学的检测关系,对探讨RA早期诊断及关节骨质破坏具有重要意义,并可能为RA诊断提供新的基础研究依据。
Serum 14-3-3η protein is a novel joint-derived proinflammatory mediator implicated in the pathogenesis of rheumatoid arthritis （RA）. 14-3-3η and cit-14-3-3ηand corresponding autoantibodies are newly discovered biomarker platform on RA with high diagnostic specificity and sensitivity. It is present at significantly higher levels in the synovial fluid and serum of patients with RA, and is positively correlated with its pathogenesis, disease activity, severity and radiographic progression, also reaction and negative prognostic factor of the treatment. Therefore using diagnostic sensitivity, specificity, positive predictive value and negative predictive value and other indicators to evaluate the detection of 14-3-3η protein levels for RA diagnosis and its association with current clinieal and serological relationship,is of great significance for discussion on the early diagnosis of RA and destruction of the joint bone destruction, and may provide a new basic research ref- erence for the diaznosis of RA.
出处
《医学综述》
2016年第21期4169-4173,共5页
Medical Recapitulate
基金
国家自然科学基金(81360460
30760235)
内蒙古自治区科技发展项目(201411424)
