摘要
目的：探讨米非司酮配伍米索前列醇用于高危产妇终止妊娠的临床效果，为临床治疗方案的选择提供参考。方法选取在妇产科就诊，要求终止早期妊娠的高危产妇182例，采用随机数字表法分为观察组和对照组各91例。对照组按照常规人工流产术终止妊娠，观察组在人工流产术前口服米非司酮片和米索前列醇片。对比两组患者的手术时间、术中出血量以及疼痛程度；对比两组患者的宫颈软化程度以及人工流产术并发症的发生情况。结果观察组的手术时间为（2．21±1．41）min，术中出血量为（15．29±4．06）mL，均显著短于、少于对照组（t ＝7．122、8．256，均 P ＜0．05）；观察组术中疼痛程度分级Ⅰ级的占58．24％，显著高于对照组的10．99％，Ⅲ级的占5．49％，显著低于对照组的49．45％（χ2＝44．887、44．121，均 P ＜0．05），观察组宫颈充分软化59例，充分软化率为64．84％，对照组宫颈充分软化41例，充分软化率为45．05％。观察组的充分软化率显著高于对照组（χ^2＝7．191、8．411，均 P ＜0．05），对照组发生子宫穿孔2例，发生人工流产综合征7例，并发症的发生率为9．89％，观察组无发生子宫穿孔的病例，1例发生人工流产综合征，并发症的发生率为1．10％。观察组人工流产并发症的发生率显著低于对照组（χ^2＝6．772，P ＜0．05）。结论米非司酮配伍米索前列醇用于高危产妇终止妊娠可显著缩短人工流产术的手术时间，减少术中出血量，减轻患者的疼痛，降低手术并发症的发生率。
Objective To explore the clinical effect of mifepristone combined with misoprostol for termina-tion of pregnancy in high risk pregnant women and provide reference for clinical treatment.Methods 182 cases of high -risk maternal were divided into observation group and control group by the random number table method,each group 91 cases.The control group was treated with conventional abortion termination of pregnancy,the observation group was treated with the artificial abortion before oral administration of mifepristone tablets and misoprostol tablets. The operation time,the amount of blood loss,the degree of pain,the degree of cervical softening and the occurrence of complications of induced abortion were compared between the two groups.Results The operation time of the observa-tion group was （2.21 ±1.41）min,intraoperative bleeding was （15.29 ±4.06）mL,which were significantly less than those of the control group （t =7.122,8.256,all P 〈0.05）;The pain degree grade I in the observation group was 58.24%,which was significantly higher than that in the control group,grade III accounted for 5.49%,which was sig-nificantly lower than the that in the control group （χ^2 =44.887,44.121,all P 〈0.05）,the observation group of cer-vical softening full was 59 cases,full softening rate was 64.84% and the control group in the cervical softening full was 41 cases,softening full rate was 45.05%.Fully softening rate in the observation group was significantly higher than that in the control group （χ^2 =7.191,8.411,P 〈0.05）,the control group,the incidence of uterine perforation in 2 cases,the occurrence of artificial abortion syndrome 7 cases,the incidence of complications for 9.89%,the obser-vation group had no uterine perforation occurred,1 case of artificial abortion syndrome and complications occurred rate was 1.10%.The incidence of complications in the observation group was significantly lower than that in the control group （χ^2 =6.772,P 〈0.05）.Conclusion Mifepristone combined with misoprostol for high -risk maternal termi-nation of pregnancy could significantly shorten the artificial abortion operation time,reduce intraoperative blood loss,reduce the patient pain,reduce the incidence of complications.
作者
史黎丽
周武英
Shi Lili Zhou Wuying(Department of Obstetrics and Gynecology, Cixi Hospital Affiliated to Wenzhou Medical University, Cixi, Zhejaing 315300, China)
出处
《中国基层医药》
CAS
2016年第20期3098-3101,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
高危产妇
终止妊娠
米非司酮
米索前列醇
High risk maternal
Termination of pregnancy
Mifepristone
Misoprostol
