摘要
目的 探讨儿童同种异体肝脏移植术后各种感染类型的防治特点。方法2000年3月31日我科成功地进行了1例小儿同种异体背驮式肝移植;受体为14岁男童,患先天性Carloli病,曾行两次胆道手术,术前患儿胆汁性肝硬化,复发性胆管炎,肝胆管结石,充血性脾肿大伴脾功亢进,为终末期肝病。结果 术后早期曾出现肺部感染等多器官并发症和急性排斥反应,术后17个月出现慢性排斤反应,经积极抗感染、抗病毒及免疫治疗得以控制,至今已存活2年余。结论 各种感染是儿童肝脏移植的主要并发症,根据药敏选择有效的抗生素控制细菌感染,早期应用更昔洛韦和长期服用FK506的免疫治疗,对巨细胞病毒感染的预防非常有效。
OBJECTIVE To study the control of various kinds of infection in a child after orthotopic liver transplantation. METHODS On March 31, 2000, a successful pediatric piggyback orthotopic liver transplantation was performed in our Department. The recipient was a 14-year-old boy with innate intrahepatic duct cystic dilatation (Carloli's), cholestatic cirrhosis, recurrent cholangitis, congestive splenomegaly attendant hypersplenism and terminal hepatopathy. RESULTS The early stage complications of the multi-organ, for example, pulmonary infection, acute rejection and chronical rejection at post operation 17 months of the recipient were controlled effectively by active anti-infection, anti-virus and immunotherapy. The patient is living in healthy for more than two years. CONCLUSIONS The various kinds of infection were main complications after the pediatric liver transplantation. Antibiotic has been selected to control the bacterial infection according to drug sensitivity. The preventions of using the ganciclovir in earlier period and taking FK506 for longterm immune therapy against the cy-tomegalovirus infection were very effective.
出处
《中华医院感染学杂志》
CAS
CSCD
2002年第8期569-570,573,共3页
Chinese Journal of Nosocomiology
