摘要
目的 评价胺碘酮预防肺切除术后心房颤动的有效性和安全性。方法 选取2014年4月-2015年6月本院130例接受肺叶或全肺切除术后患者为研究对象,按照随机原则分为胺碘酮组（接受预防性使用胺碘酮,n=65）和对照组（n=65）,比较两组患者在住院期间需要治疗的房颤及房颤持续〉30 s的发病率、住重症监护室时间和总住院时间。结果 胺碘酮组房颤发病率为13.8%,明显低于对照组的32.3%,差异有统计学意义（P〈0.05）,胺碘酮组术后持续〉30 s的房颤发病率为13.8%,低于对照组的33.8%,差异有统计学意义（P〈0.01）;胺碘酮组总住院时间和ICU停留时间明显短于对照组（P〈0.05）;两组术后不良事件发生率比较,差异无统计学意义（P〉0.05）。结论 预防性使用胺碘酮可明显降低肺切除术后房颤的发病率,并且显著减少重症监护室停留时间。
Objective To evaluate efficacy and safety of Amiodarone for preventing atrial fibrillation after pulmonary resection.Methods 130 cases of accepting lobectomy or pneumonectomy in the hospital from April 2014 to June 2015 were randomly divided into Amiodarone group （prophylactic use of Amiodarone,n=65） and control group （n=65）,incidence of atrial fibrillation during hospitalization in need of treatment and atrial fibrillation more than 30 s,stay in intensive care unit and total length of hospital stay between two groups were compared.Results The incidence of atrial fibrillation in the Amiodarone group was 13.8%,significantly lower than 32.3% in the control group （P〈0.05）,incidence of atrial fibrillation more than 30 s in the Amiodarone group was 13.8%,lower than 33.8% in the control group （P〈0.01）;in the Amiodarone group,stay in intensive care unit and the total length of hospital stay was significantly shorter than that in the control group respectively,the difference was statistically significant （P〈0.05）;incidence of postoperative adverse events was not statistically significant （P〉O.05）.Conclusion Prophylactic use of Amiodarone can significantly reduce incidence of atrial fibrillation after pulmonary resectio,and significantly reduce residence time in intensive care unit.
出处
《中国当代医药》
2016年第28期38-40,共3页
China Modern Medicine
基金
江西省卫生计生委科技计划项目(20142026)
关键词
胺碘酮
预防
肺切除术术后
房颤
Amiodarone
Prevention
After pulmonary resectio
Atrial fibrillation
