摘要
目的：探讨促红细胞生成素对脑损伤早产儿神经功能及脑干听觉诱发电位的影响及安全性。方法：选择脑损伤早产儿46例,按随机数字表法分为治疗组和对照组,各23例。对照组患儿接受呼吸支持、营养支持、补充维生素K和神经节苷脂等常规对症治疗;治疗组患儿在对照组基础上给予注射用重组人促红素（CHO细胞）500 IU/kg,皮下注射,每周3次。两组患儿均连续治疗3~4周。比较两组患儿治疗前后的智力发育指数（MDI）、心理运动发育指数（PDI）、血清神经损伤因子[特异性烯醇化酶（NSE）、S-100β]含量、脑干听觉诱发电位潜伏期和峰间期水平,并观察两组患儿不良反应发生情况。结果：治疗前,两组患儿MDI、PDI、血清神经损伤因子含量、脑干听觉诱发电位潜伏期和峰间期水平比较,差异均无统计学意义（P〉0.05）;治疗后,两组患儿MDI、PDI明显升高,血清神经损伤因子含量及脑干听觉诱发电位潜伏期和峰间期水平明显降低,且治疗组明显优于对照组,差异均有统计学意义（P〈0.05）。两组患儿均未见明显不良反应发生。结论：促红细胞生成素能明显提高患儿智力发育水平,有效保护受损神经细胞与听觉神经通路,且安全性较好。
OBJECTIVE： To investigate the effects and safety of erythropoietin on nerve function and brainstem auditory evoked potential in the preterm children with brain damage. METHODS： 46 preterm children with brain damage were randomly divided into treatment group and control group, with 23 cases in each group. Control group received conventional symptomatic treatment as respiratory support, nutritional support, vitamin K supplement and ganglioside. Treatment group was additionally given rhEPO for injection （CHO cell） 500 IU/kg hypodermically, 3 times a week, on the basis of control group. Both group received 3-4 weeks of treatment continuously. MDI, PDI, the content of serum nerve injury factor （NSE, S-10013）, latent period and peak interval of brainstem auditory evoked potential were compared between 2 groups before and after treatment, and the occurrence of ADR was observed in 2 groups. RESULTS ： There was no statistical significance in MDI, PDI, the content of serum nerve injury molecule, latent period and peak interval of brainstem auditory evoked potential between 2 groups before treatment （P〉0.05）. After treatment, MDI and PDI of 2 groups increased significantly, while the content of serum nerve injury factor, latent period and peak interval of brainstem auditory evoked potential decreased significantly; the treatment group was better than the control group, with statistical significance （P〈0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Erythropoietin can significantly improve intelligence development, protect the damaged nerve cells and auditory nerve pathways with good safety.
出处
《中国药房》
CAS
北大核心
2016年第29期4091-4093,共3页
China Pharmacy
基金
河北省医学科学研究重点课题计划(No.20150480)
关键词
早产儿
促红细胞生成素
脑损伤
脑干听觉诱发电位
神经细胞
Preterm children
Erythropoietin
Brain injury
Brainstem auditory evoked potential
Nerve cell
