摘要
目的:比较分析健康妇女、正常妊娠孕妇、胎儿生长受限孕妇的凝血功能的各项指标水平,探讨其对诊断FGR的意义和预测价值。方法:选取诊断为FGR的晚期妊娠孕妇50例,正常晚期妊娠妇女50例,正常未妊娠妇女50例,对这3组凝血功能中的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体这5项指标进行比较和分析。结果:与正常未孕组相比,妊娠组的PT、APTT明显低于正常未孕组(P<0.05),而妊娠组的FIB、D-二聚体明显高于正常未孕组(P<0.05)。FGR组的PT、APTT明显低于正常晚孕组(P<0.05),D-二聚体、FIB明显高于正常晚孕组(P<0.05)。结论:妊娠期妇女存在着血液高凝状态,而胎儿生长受限孕妇较正常妊娠孕妇更易致血栓前状态。我们应定期监测凝血功能以早期预测FGR的发生,从而进行早期处理,减少不良妊娠的发生。
Objective：To analyze the indexes of blood coagulation function in normal non pregnant women,normal late pregnant women and pregnant women with fetal growth restriction.And to study the significance and forecast value of blood coagulation function for the diagnosis of FGR.Methods：Chose 50 cases of late pregnant women with FGR,50 cases of normal late pregnant women and 50 cases of normal non pregnant women in Wenzhou people＇s hospital.Among these three groups＇ blood coagulation function,the five indexes including prothrombin time（PT）,activated partial prothrombin time（APTT）,thrombin time（TT）,fibrous protein（FIB）,and D-dimer were compared and analyzed.Results：Compared with normal non pregnant group,the PT and APTT in the pregnant group were significantly lower than that of the normal non pregnant group（P〈0.05）,while the FIB and D-dimer in the pregnant group were significantly higher than that of the normal group（P〈0.05）.PT and APTT in FGR group were significantly lower than that of the normal late pregnant group（P〈0.05）,and the D-dimer and FIB in FGR group were significantly higher than that of the normal late pregnant group（P〈0.05）.Conclusion：Pregnant women are always in the blood hypercoagulation state,while the pregnant women with fetal growth restriction are much more prone to be prethrombotic state than normal late pregnant women.We should regularly monitor the blood coagulation function in order to predict the occurrence of FGR in early stage,so as to reduce the incidence of adverse pregnancy.
出处
《数理医药学杂志》
2016年第10期1465-1467,共3页
Journal of Mathematical Medicine
关键词
胎儿生长受限
凝血功能
血液高凝状态
血栓前状态
fetal growth restriction
blood coagulation function
hyercoagulation
prethrombotic state
