摘要
目的 本研究旨在观察盐酸戊乙奎醚对舒芬太尼诱发咳嗽反射的发生率和严重程度的影响。方法 选择120例择期行腹腔镜胆囊切除,ASAⅠ~Ⅱ级,年龄18~60岁成年患者,分入盐酸戊乙奎醚组（P组）,生理盐水组（C组）每组60例。全身麻醉诱导前10min两组分别静脉注射盐酸戊乙奎醚及生理盐水,观察静脉注射实验药物后脑电双频指数（BIS）变化。静脉诱导时0.25μg/kg舒芬太尼2s内注射完毕,观察两组患者咳嗽发生率及严重程度。结果 两组患者麻醉诱导前BIS变化无明显差异,C组患者发生咳嗽的例数明显多于P组,且咳嗽严重程度明显大于P组（P〈0.05）。结论 全身麻醉前静脉注射盐酸戊乙奎醚能有效减少舒芬太尼诱导咳嗽反射的发生,减轻其严重程度。
Objective To observe the effect of penehyclidine hydrochloride on cough and severity of the cough induced by sufentanil. Methods Totally 120 cases were enrolled,patients with laparoscopic cholecystectomy were randomly divided into two groups,group P（penehyclidine hydrochloride group）and group C（saline group）, 60 cases in each group. All the patients was aged from 18 to 60 years old and ASA I -Ⅱ. The two groups respectively intravenous injection of penehyclidine hydrochloride or saline before 10 min in general anesthesia induced, the changes of BIS after intravenous injection of penehyclidine hydrochloride or saline were observed. The incidence and severity of cough in the two groups of patients with 0.25μg/kg sufentanil induced by intravenous injection in 2 s were observed. Results There were no significant differences in BIS changes before anesthesia induction in the two groups. The number of patients with cough in group C was significantly more than that in group P, and the seyerity of cough was significantly greater than that of group P（P〈0. 05）. Conclusion ly reduce incidence of cough induced by sufentanil before general Intravenous injection of penehyclidine hydrochloride can effectiveanesthesia reduced its severity.
出处
《重庆医学》
CAS
北大核心
2016年第28期3954-3955,共2页
Chongqing medicine
关键词
盐酸戊乙奎醚
舒芬太尼
咳嗽
penehyclidine hydrochloride
sufentanil
cough
