摘要
代谢产物,如游离脂肪酸(FFA)、脂多糖(LPS)等常诱发慢性低度炎症,称代谢性炎症,后者参与并导致动脉粥样硬化、2型糖尿病(T2DM)、非酒精性脂肪肝及肥胖等代谢性疾病的发生。我们在国内外首次提出"代谢性炎症综合征(metabolic inflammatory syndrome,MIS)"的概念及诊断思路,建议将伴有2个及2个以上上述代谢性疾病的患者诊断为MIS。在T2DM人群中,MIS的检测率及预测冠心病的相对危险度明显高于代谢综合征(MS)。提示MIS的概念较MS更适合于代谢性疾病的早期筛查、预防和研究。如果患者有MIS的4个组分中的1个,应筛选其他组分,特别是动脉粥样硬化。MIS的概念将促进异病同防和异病同治的临床实践。
Metabolic products,such as free fatty acid（FFA）,lipopolysaccharide（LPS）etc often induce chronic low-grade inflammation,which calls metabolic inflammation and participates in and leads to atherosclerosis,type 2diabetes mellitus（T2DM）,nonalcoholic fatty liver disease and obesity as well.Our study group first proposed the concept and diagnostic idea of ＂Metabolic inflammatory syndrome（MIS）＂in national and international field.We recommended that patients who meet two or more metabolic disorders above could be diagnozed as MIS.In the patients with T2 DM,the detection rate of MIS and prediction on the relative risk of coronary heart disease were significantly higher over metabolic syndrome（MS）.These suggested that the concept of MIS was more suitable than MS for early screening,prevention and research in metabolic diseases.If the patients have one of four metabolic diseases of MIS,they should be screened other disease,especially atherosclerosis.Therefore,the concept of MIS will promote the prevention and treatment for patients with different diseases.
出处
《临床荟萃》
CAS
2016年第9期960-963,共4页
Clinical Focus
基金
国家自然科学基金重点课题(81030014
81270902
81471059)
关键词
代谢性炎症
代谢炎症性综合征
糖尿病
2型
动脉粥样硬化
脂肪肝
非酒精性
肥胖
metabolic inflammation
metabolic inflammatory syndrome
diabetes mellitus
type 2
atherosclerosis
fatty liver
non-alcoholic
obesity
