摘要
目的研究蒲公英眼用温敏凝胶的制备工艺。方法以泊洛沙姆407、泊洛沙姆188、HPMC为混合凝胶基质,以泪液稀释前后的胶凝温度为指标,采用均匀设计法设计蒲公英眼用温敏凝胶的处方。结果该制剂在室温条件下是自由流动的液体,在生理条件下发生相变形成凝胶,符合眼用制剂的质量要求;凝胶溶蚀控制药物的释放速率,二者均遵循零级动力学方程。结论蒲公英眼用温敏凝胶的制备工艺简单、可行。
Objective To study the preparation of the dandelion ophthalmic thermosensitive gel. Methods The ophthalmic gel was prepared with poloxamer 407/188 and HPMC, and the gelation temperature before and after tear dilution was employed as the index. The prescriptions were designed by uniformity design method. Results The optimized formulation was a freely flowing liquid at room temperature and converted to a firm gel under physiological condition, and it was accorded with the requirement for ophthalmic application. The in vitro release experiment showed that the release of drug from polo xamer gels followed zero-order kinetics. Conclusion The preparation process of the dandelion ophthalmic therrnosensitive gel is simple and feasible.
出处
《实用药物与临床》
CAS
2016年第8期1007-1010,共4页
Practical Pharmacy and Clinical Remedies
关键词
蒲公英
温敏凝胶
均匀设计
胶凝温度
Dandelion
Thermosensitive gel
Uniform design
Gelation temperature
