摘要
目的探究木丹颗粒联合硫酸锌对糖尿病足背动脉硬化患者踝臂指数的影响及临床疗效。方法收集山东大学附属第二医院周围血管病科收治的糖尿病足背动脉硬化患者66例,根据随机对照表分为对照组和试验组,其中试验组33例,对照组33例。对照组给予甲钴胺注射液及硫酸锌片,试验组在对照组的基础上给予木丹颗粒。2组患者均以7 d为1个疗程,连续治疗4个疗程。治疗结束后对比分析2组患者临床疗效、血糖、血脂、血液流变学、足背动脉血液流动力学、踝臂指数以及不良反应情况。结果治疗后与对照组相比,试验组临床总有效率较高(P<0.05)。与对照组相比,试验组血清餐后2 h血糖、总胆固醇、甘油三酯、低密度脂蛋白水平较低(P<0.05),高密度脂蛋白水平较高(P<0.05),试验组血清全血粘度高切、全血粘度中切、全血粘度低切、血浆粘度、红细胞压积以及纤维蛋白原水平下降(P<0.05),试验组足背动脉血流量、血管内径以及踝臂指数较高(P<0.05),足背动脉峰值流速较低(P<0.05)。2组不良反应发生率相比差异无统计学意义。结论木丹颗粒联合硫酸锌对糖尿病足背动脉硬化患者临床疗效显著,提高踝臂指数。
Objective To explore the effect of Mudan granule combined with zinc sulfate on ankle brachial index in the treatment of diabetic foot dorsal artery sclerosis and its efficacy. Methods 66 cases of patients with diabetic foot dorsal artery sclerosis in this study were selected and divided into2 group,33 cases in each group. Control group received mecobalamin injection and zinc sulfate tablet and treatment group received Mudan granule on the basis of control gorup. 7 days for a course of treatment and patients received continuous treatment of 4 courses. Clinical efficacy,blood glucose,blood lipids,blood rheology,blood flow dynamics of the dorsal artery of the foot,ankle brachial index,and adverse reactions were compared after the treatment. Results Compared with the control group after the treatment,the total effective rate of the treatment group was higher（ P〈0. 05）. Compared with the control group,the serum postprandial 2h blood glucose,total cholesterol,triglyceride,low density lipoprotein cholesterol levels were lower（ P〈0. 05）,and high density lipoprotein were higher（ P〈0. 05）,the levels of whole blood viscosity high,middle and low shear,plasma viscosity,hematokrit and fibrinogen were lower（ P〈0. 05）,the serum levels of appeal index were lower（ P〈0. 05）,the blood flow of the dorsal artery,the diameter of the blood vessels and the ankle brachial index were higher（ P〈0. 05）,the peak velocity of the dorsal foot artery was lower（ P〈0. 05）. There was no significant difference in the incidence of adverse reactions between the 2 groups. Conclusion Mudan granule combined with zinc sulfate tablet in the treatment of diabetic foot dorsal artery sclerosis was effective with high safety and it could improve ankle brachial index.
出处
《中国生化药物杂志》
CAS
2016年第6期151-154,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
木丹颗粒
硫酸锌
糖尿病足背动脉硬化
踝臂指数
Mudan granule
zinc sulfate
diabetic foot dorsal artery sclerosis
ankle brachial index
