摘要
目的探讨降钙素原(procalcitonin,PCT)在不同病理进程脓毒症诊断中的临床应用价值。方法选择2010年8月至2015年8月我院120例脓毒症患者作为研究对象,按照疾病的严重程度将脓毒症患者分为脓毒症组47例,严重脓毒症组39例,脓毒症休克组34例,采用免疫荧光法检测患者入院后第1至7天血清PCT浓度,对检测结果进行统计学分析。结果随脓毒症严重程度的增加,血清PCT水平呈上升趋势,不同时间点三组间PCT水平比较差异均有统计学意义(P均<0.05),不同时间点脓毒症休克组血清PCT水平均高于严重脓毒症组和脓毒症组,严重脓毒症组高于脓毒症组,且差异均有统计学意义(P均<0.05)。随入院天数的增加,三组脓毒症患者血清PCT水平均呈下降趋势。存活组从入院第3天起PCT水平显著低于死亡组,差异均有统计学意义(P均<0.05);随入院天数的增加,存活组脓毒症患者血清PCT水平呈逐渐下降趋势,而死亡组脓毒症患者呈逐渐上升趋势,且差异均有统计学意义(P均<0.05)。结论血清PCT检测对脓毒症的诊断、治疗及预后评估具有较高的临床应用价值。
Objective To study the clinical application value of procalcitonin （PCT） in patients with sepsis in different pathological processes. Methods 120 patients with sepsis who were admitted in our hospi-tal between August 2010 and August 2015 were selected as study subjects. All the patients were divided into sepsis group （47 cases）, severe sepsis group （39 cases） and septic shock group （34 cases） according to the pathogenetic condition. The concentrations of PCT were detected by immunofluorescence assay on the 1st to 7th day after admission. The results of PCT in different sepsis groups were analyzed statistically. Results The PCT levels showed a increasing trend along with the severity degree of sepsis. There were statistical significance in the differences of PCT levels among three different sepsis groups at different time（Pall〈0.05）. The PCT level in septic shock group was higher than that of severe sepsis group and sepsis group, and the severe sepsis group was higher than that of sepsis group, and the differences all had statistical significance （Pall〈0.05）. The PCT levels in three sepsis groups were all decreased along with the increase of hospitalization time. The PCT levels on 3rd, 5th and 7th day after admission in death group were all higher than that of survival group, and the dif-ferences all had statistical significance （Pall〈 0.05）. The PCT level in survival group showed a decreasing trend, but showed a increasing trend in death group along with the increasing hospitalization time, and the dif-ferences all had statistical significance（Pall〈0.05）. Conclusion The detection of PCT has better clinical ap-plication value in the diagnosis, therapy and prognosis evaluation.
出处
《实用检验医师杂志》
2016年第2期94-96,99,共4页
Chinese Journal of Clinical Pathologist
关键词
脓毒症
PCT
预后评估
诊断
Sepsis
PCT
Prognosis evaluation
Diagnosis
