摘要
以双炔基取代的苯类衍生物为原料,与叠氮化钠环合生成1,2,3-三唑稠杂环化合物,然后在110℃条件下经脱氮开环反应得到四个异喹啉类衍生物,并提出了可能的反应机理.所有化合物经核磁共振氢谱和核磁共振碳谱表征以及高分辨质谱表征,波谱数据与化合物结构吻合.实验结果表明,通过1,2,3-三唑稠杂环化合物在加热条件下的脱氮开环,可以得到了四个新型的异喹啉类衍生物,提供了一种间接的合成1,3-二取代的异喹啉类衍生物的方法,为异喹啉类衍生物的进一步研究奠定了基础.
The[1,2,3]triazole[5,1-а]-isoquinoline derivatives were synthesized by cycliaztion reaction with1,2-bis（phenylethynyl）benzene derivatives and Na N3,then four isoquinoline derivatives were prepared by deni-trogenation ring-opening reaction at the temperature of 110 ℃,and the reaction mechanism was also proposed inthis paper.The structures of the compounds were confirmed by proton nuclear magnetic resonance spectroscopyand carbon-13 nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry.Experimentalresults showed that through the denitrogenation ring-opening of 1,2,3-triazole under heating condition,four newisoquinoline derivatives were obtained easily,which provided a method for indirect synthesis of 1,4-disubsti-tuted isoquinoline derivatives,and laid the foundations for further study.
出处
《武汉工程大学学报》
CAS
2016年第4期324-328,共5页
Journal of Wuhan Institute of Technology
基金
湖北省教育部重点基金项目(D20151502)
武汉工程大学研究生创新基金(CX2014115)
关键词
1
2
3-三唑稠杂环
异喹啉衍生物
合成
开环反应
1
2
3-triazole fused heterocyclic
isoquinoline derivative
synthesis
ring opening reaction
