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Irisin对糖脂代谢的作用及机制研究 被引量：1

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摘要 人体内白色脂肪组织主要作用是能量储存,以及分泌多种脂肪细胞因子及炎症因子参与胰岛素抵抗及相关疾病的发生。而棕色脂肪组织具有非战栗产热的能力,棕色脂肪含有丰富的线粒体,并可表达解耦联蛋白1（uncoupling protein1,UCP1）,通过UCP1使线粒体的氧化磷酸化解偶联,氧化分解脂肪,减少脂肪堆积。
作者 王明明 刘师伟 李欣
机构地区 山西医科大学研究生学院 山西医学科学院山西大医院内分泌科
出处 《中国药物与临床》 CAS 2016年第7期993-996,共4页 Chinese Remedies & Clinics
基金 国家自然科学基金(81471025 81200591) 山西省留学回国人员科技活动择优资助项目(2013-251) 山西省回国留学人员科研资助项目(2015-109) 山西省国际科技合作计划项目(2015081029)
关键词 非战栗产热 棕色脂肪组织 脂肪细胞因子 白色脂肪 解耦联蛋白 糖脂代谢 胰岛素抵抗 Irisin 解偶联 UNCOUPLING
分类号 R58 [医药卫生—内分泌]
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参考文献30

  • 1Bostrom P,Wu J,Jedrychowski MP,et al. A PGCl-alpha-depeo- dent myokine that drives brown-fat-like development of white fat and thermogenesis[J]. Nature,2012,481(7382) :463-468.
  • 2Roca-Rivada A,Castelao C,Senin LL,et al. FNDC5/irisin is not only a myokine but also an adipokine [J]. PLoS One,2013,8 (g) : e60563.
  • 3Pardo M,Crujeiras AB,Amil M,et al. Association of irisin with fat mass, resting energy expenditure, and daily activity in con- ditions of extreme body mass index[J]. Int J Endocrinol,2014, 2014: 857270.
  • 4潘玲玲,张惠杰,陈政,李小英,杨叔禹,李学军.血清irisin水平与腹型肥胖成人体脂率相关[J].中华糖尿病杂志,2013,5(8):472-476. 被引量：4
  • 5Xiang L,Xiang G,Yue L,et al. Circulating irisin levels are posi- tively associated with endothelium-dependent vasodilation in newly diagnosed type 2 diabetic patients without clinical an-giopathy[J]. Atherosclerosis,2014,235(2) :328-333.
  • 6Choi YK,Kim MK,Bae KH,et al. Serum irisin levels in newon- set type 2 diabetes [J]. Diabetes Res Clin Pract,2013,100(1): 96-101.
  • 7Zhang C, Ding Z, Lv G. Lower irisin level in patients with type 2 diabetes mellitus: a case-control study and meta-analysis[J]. J Diabetes,2016,8(1) :56-62.
  • 8Sesti G,Andreozzi F,Fiorentino TV,et al. High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects[J]. Acta Diabetol, 2014,51 ( 5 ) : 705-713.
  • 9田文葭,周华丽,李成江.2型糖尿病患者血清鸢尾素水平与胰岛素抵抗的相关性[J].中华糖尿病杂志,2014,6(9):655-659. 被引量：11
  • 10Zhang Y,Li R,Meng Y,et al. Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling [J]. Diabetes,2014,63 (2) :514-525.

二级参考文献39

  • 1Flegal KM, Carroll MD, Ogden CL,et al. Prevalence and trends in obesity among US adults, 199%2008. JAMA, 2010, 303: 235- 241.
  • 2Liang YJ, Xi B, Song AQ, et al. Trends in general and abdominal obesity among Chinese ehildren and adolescents 1993- 2009. Pediatr Obes,2012,7:355-364.
  • 3Shi XD, He SM, Tao YC, et al. Prevalence of obesity and associated risk factors in Northeastern China. Diabetes Res Clin Praet ,2011,91:389-394.
  • 4Kahn SE, Hull RL, Utzsehneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature, 2006,444 : 840- 846.
  • 5Withrow D, Alter DA. The economic burden of obesity worldwide : a systematic review of the direct costs of obesity. Obes Rev ,2011, 12:131-141.
  • 6Wells JC, Marphatia AA, Cole TJ,et al. Associations of eeonomic and gender inequality with global obesity prevalence : understanding the female excess. Soc Sci Med,2012,75:482-490.
  • 7Bostlon P, Wu J, Jedrychowski MP,et al. A PGCl-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature ,2012,481 :463-468.
  • 8Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med,1998 ,15 :539-553.
  • 9Nolan C J, Damm P, Prentki M. Type 2 diabetes across generations : from pathophysiology to prevention and management. Lancet, 2011,378 : 169 -181.
  • 10Juonala M, Magnussen CG, Berenson GS, et al. Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med,2011,365 : 1876-1885.

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中国药物与临床
2016年 第7期

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