摘要
目的:探讨Her2在乳腺癌和胃癌中表达的临床情况与相关意义,为肿瘤防治提供参考。方法:收集2009年3月到2014年5月在我院行外科手术切除的60例确诊的进展期胃癌标本与60例确诊的晚期乳腺癌标本,都进行Her2病理表达免疫组化分析,并调查了相关临床病理资料进行相关性分析。结果:Her2的乳腺癌和胃癌标本中阳性表达率分别为40.0%和36.7%,对比差异无统计学意义(P>0.05)。Her2表达与恶性肿瘤患者的年龄、病理类型无关,与TNM分期与淋巴结转移有明显相关性(P<0.05)。Spearman相关分析显示乳腺癌与胃癌中的Her2表达都与Survivin、Bcl-2表达存在明显正向相关性(P<0.05)。结论:乳腺癌和胃癌患者Her2都呈现高病理表达状况,与TNM分期与淋巴结转移有明显相关性,能通过调节部分凋亡抑制蛋白,参与肿瘤的发病与转移过程。
Objective：To investigate the clinical significance of Her2 pathological expression in the breast and gastric cancer patients for providing a reference for cancer prevention. Methods： Selected surgical resection specimens of 60 diagnosed in advanced gastric cancer and 60 diagnosed with advanced breast cancer from March 2009 to May 2014 in our hospital,all specimens were given the Her2 pathological expression of immunohistochemical analysis and investigation the clinical and pathological data. Results： The Her2 positive expression rates in the breast cancer and gastric cancer specimens were 40. 0% and 36. 7%,respectively that compared to no significant difference （P〉0. 05）. The Her2 expression was not related to the cancer patient’s age,histological type,and there were sig-nificantly correlated to the TNM stage and lymph node metastasis （ P〈0. 05 ） . Spearman correlation analysis showed that Her2 expression in the breast cancer and gastric cancer were significant positive correlation to the Survivin, Bcl-2 expression （ P〈0. 05 ） . Conclusion：Breast cancer and gastric cancer patients have shown high pathological expression of Her2,and are related to the TNM stage and lymph node metastasis, it may be through inhibited the apoptosis regulating proteins involved in the pathogenesis and metastasis of tumors.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2016年第6期858-862,共5页
Chinese Journal of Immunology
基金
湖北省卫生厅科研基金重点项目(No:JX3A10)--乳腺癌淋巴管特异性分子标志物筛选及淋巴道转移早期诊断
关键词
乳腺癌
胃癌
Her2
病理特点
Breast cancer
Stomach cancer
Pathological features
