摘要
目的观察结核分枝杆菌临床分离株对利福平的依赖状况。方法248份痰液标本来自2008年1月～2009年12月在北京胸科医院住院的肺结核患者。采用改良罗氏培养基分离菌株，进行利福平耐药性及依赖性测定。结果痰液标本罗氏培养阳性率82．7％（205／248）。在96例（占46.8％，96／205）对利福平耐药的样本中，有27例依赖利福平，占28．1％（27／96），其中，低浓度依赖占11．1％（3／27），高浓度依赖占88．9％（24／27）。结论结核分枝杆菌临床分离株对利福平存在较高依赖性，且与利福平浓度相关。
Objective To investigate the drug dependency of clinical isolated strains of 34. tuberculosis （MTB） on rifampicin. Method 248 sputum samples of pulmonary tuberculosis were collected in Beijing Chest Hospital from January, 2008 to December, 2009. The samples were inoculated to Lowenstein-Jensen medium. Drug susceptibility test and dependency test were performed for the culture-positive samples. Results The culture-positive rate of the specimens was 82.7% （205/248）. The drug susceptibility test showed that 96 culture-positive samples were resistant to rifampicin, and the rate was 46.8% （96/205）. Among these rifampicin-resistant samples, 27 samples were dependent on rifampicin and the drug-dependent rate was 28.1% （27/96）. The drug-dependent rate at low concentration was 11.1% （3/27）, and 88.9% （24/27） at high concentration. Conclusion The clinical isolated strains of MTB showes high rifampicin-dependent rate, and the dependency is related with rifampicin concentration.
出处
《结核病与胸部肿瘤》
2016年第1期19-21,共3页
Tuberculosis and Thoracic Tumor
关键词
结核
利福平
依赖性
Tuberculosis
Rifampicin
Drug dependency
