摘要
目的探讨呋喃西林联合康复新液在重症口腔溃疡患者中的疗效。方法将我科2006年1月~2015年12月治疗的重症口腔溃疡患者90例按随机数字表法分为两组,每组各45例。其中对照组单独给予呋喃西林漱口,治疗组在对照组治疗的基础上联合康复新液进行治疗,比较两组疗效及治疗前后唾液中分泌型免疫球蛋白A（s Ig A）、免疫球蛋白G（IgG）的含量。结果治疗组患者症状明显好转,治疗组的显效率28.89%（13/45）、总有效率91.11%,对照组显效率15.56%、总有效率80.00%,且治疗组溃疡愈合时间[（3.2±0.5）d]也较对照组的[（4.9±1.3）d]明显缩短,差异有统计学意义（P〈0.05）。治疗7 d后,治疗组唾液中的sIgA含量[（65.7±10.5）g/L]明显高于对照组的[（52.0±9.4）g/L],而IgG含量[（23.5±5.5）g/L]明显低于对照组的[（35.3±7.5）g/L],差异均有统计学意义（P〈0.05）。结论重症口腔溃疡患者给予呋喃西林联合康复新液治疗的效果较好,安全性高,可提高患者满意度及护理质量,值得临床推广。
Objective To investigate the clinical efficacy of nitrofurazone combined with Kangfuxin in patients with severe mouth ulcers.Methods 90 patients of severe mouth ulcers treated from January 2006 to December 2015 in our department were selected,the patients were divided into two groups by random digits table,with 45 cases in each group.The control group was only given nitrofurazone mouthwash,the treatment group were treated combined with Kangfuxin on the basis of control group.The efficacy and the content of secretory immunoglobulin A（s Ig A） and immunoglobulin G（Ig G） were compared between two groups before and after treatment.Results The symptoms were significantly improved in the treatment group,the effective rate and the total effective rate in treatment group was 28.89%,91.11% respectively,with15.56% and 80.00% respectively in control group,the ulcer healing time in the treatment group was significantly shorter than that in the control group [（3.2 ± 0.5） d vs（4.9±1.3） d],there were statistically significant difference between two groups（P〈0.05）.The content of saliva s Ig A in the treatment group after treatment 7 d was significantly higher than that in control group [（65.7±10.5） g/L vs（52.0±9.4） g/L],and the content of Ig G was significantly lower than that in the control group [（23.5±5.5） g/L vs（35.3±7.5） g/L],there was statistically significant difference between two groups（P〈0.05）.Conclusion Nitrofurazone combined with Kangfuxin in treatment of patients with severe mouth ulcers has a good clinical efficacy,high security,can reduce patients′ suffering and improvie patients′ satisfaction and quality of care,it can be used widely in clinic.
出处
《中国当代医药》
2016年第17期101-103,共3页
China Modern Medicine
