摘要
目的：探讨血清同型半胱氨酸（Hcy）表达与2型糖尿病（T2DM）患者视网膜病变是否有相关性。方法选择79例 T2DM患者，根据视网膜病变程度分为增殖期糖尿病视网膜病变（DR）组26例，背景期DR 组25例，糖尿病无视网膜病变组28例，另选择同期健康体检者28例作为对照组。检测比较各组人群血糖值、Hcy，分析其临床意义。结果对照组、糖尿病无视网膜病变组、背景期 DR 组、增殖期 DR 组 FPG、Hcy呈递增趋势，差异均有统计学意义（F ＝448．53、174．25，均 P ＜0．01），组间比较可见对照组 FPG 为（4．86±0.42）mmol／L，明显低于背景期 DR 组的（8．73±0．48）mmol／L（t ＝31．59，P ＜0．01）及增值期 DR 组的（10．9±0．95）mmol／L（t ＝30．59，P ＜0．01），增殖期 DR 亦明显高于糖尿病无视网膜病变组（t ＝17．72，P ＜0.01）。Hcy组间比较可见对照组 Hcy 水平为（7．93±0．70）μmol／L，明显低于背景期 DR 组的（9．45±0.83）μmol／L（t ＝7．69，P ＜0．01），及增殖期 DR 组的（13．55±1．56）μmol／L（t ＝11．02，P ＜0．01），增殖期 DR 亦明显高于糖尿病无视网膜病变组（t ＝12．52，P ＜0．01）。结论Hcy 可能参与了2型糖尿病合并视网膜病变的过程，有可能作为视网膜病变程度的重要参考指标。
Objective To explore the relationship between homocysteine （Hcy）expression and diabetic ret-inopathy（DR）in patients with type 2 diabetes mellitus （T2DM）.Methods 79 patients with T2DM were selected and divided into proliferative DR group （n =26）,background stage of DR group （n =25）and without DR group（n =28）according to the degree of retinopathy.28 cases of healthy physical examination were involved as control group. Blood glucose levels,Hcy and clinical significance were detected and compared among the groups.Results The FPG and Hcy levels in the control group,without retinopathy group,background stage of DR group and proliferative DR group showed an increasing trend,there were significant differences among groups （F =448.53,174.25,all P 〈0.01）.The FPG level of the control group was （4.86 ±0.42）mmol/L,which was significantly lower than the back-ground stage of DR group[（8.73 ±0.48）mmol/L,t =31.59,P 〈0.01 ]and the proliferative DR group[（10.9 ± 0.95）mmol/L,t =30.59,P 〈0.01].The FPG level of proliferative diabetic retinopathy DR group was also signifi-cantly higher than without retinopathy group（t =17.72,P 〈0.01）.The Hcy level of the control group was （7.93 ± 0.70）μmol/L,which was significantly lower than the background stage of DR group[（9.45 ±0.83）μmol/L,t =7.69,P 〈0.01]and the proliferative DR group[（13.55 ±1.56）μmol/L,t =11.0,P 〈0.01].The Hcy level of the proliferative DR group was also significantly higher than without retinopathy group（t =12.52,P 〈0.01）.Conclusion Hcy may involved in the process of T2DMwith DR,it may be used as an important reference index for the degree of retinopathy.
出处
《中国基层医药》
CAS
2016年第14期2155-2157,共3页
Chinese Journal of Primary Medicine and Pharmacy
