摘要
目的：探究阿司匹林肠溶片联合氯吡格雷治疗不稳定型心绞痛的临床疗效及预后。方法选取84例的不稳定型心绞痛患者，采取随机数字表法分为常规治疗组与联合治疗组，每组各42例。其中常规治疗组采用阿司匹林肠溶片单药治疗，联合治疗组在常规治疗组的基础上联合使用氯吡格雷，对比两组患者治疗前后24 h 的心肌酶学指标、心电图恢复情况以及治疗结束后两组的临床疗效以及不良反应。结果治疗24 h 后，联合治疗组的心肌酶学指标 AST、CK-MB、cTnT、cTnI 分别与常规治疗组相比较，差异有统计学意义（t ＝3．98，P ＜0．05；t ＝0．05，P ＜0．05；t ＝0.05，P ＜0．05；t ＝0．05，P ＜0．05）。治疗结束后，联合治疗组心电图总恢复率与常规治疗组比较差异有统计学意义（90．5％比64．3％，χ2＝5．49，P ＜0.05）。联合治疗组治疗总有效率高于常规治疗组（83．33％比66．7％，χ2＝4．48，P ＜0．05）。常规治疗组与联合治疗组相比总不良反应无统计学意义（χ2＝2．88，P ＞0．05）。结论药物联合疗法治疗不稳定型心绞痛，协同改善临床症状，提高患者生活质量，安全可靠，值得广泛推广与应用。
Objective To explore and analyze the clinical curative effect and prognosis of enteric -coated aspirin combined with clopidogrel in the treatment of unstable angina pectoris of coronary heart disease.Methods 84 patients with unstable coronary heart disease angina pectoris were selected in the research,and they were divided into regular treatment group and combination group,42 cases in each group.The patients in conventional treatment group were given enteric -coated aspirin therapy,and the combined treatment group were given clopidogrel on the basis of routine treatment.The myocardial enzymology indexes of 24h before and after drug treatment,electrocardio-gram （ECG）recovery,curative effect and adverse reaction were compared between the two groups.Results After treatment,the myocardial enzymology indexes of the combined treatment group （AST,CK -MB,cTnT,cTnI）had sig-nificant differences compared with the general treatment group （t =3.98,P 〈0.05,t =0.05,P 〈0.05,t =0.05,P 〈0.05,t =0.05,P〈0.05）.After treatment,the ECG total recovery rate of the combination group increased obviously compared with the conventional treatment group,the difference between the two groups was significant （χ2 =5.49, P 〈0.05）.The total effective rate of the combined treatment group increased obviously compared with the conventional treatment group,the difference between the two groups was significant （90.5% vs 64.3%,χ2 =4.48,P 〈0.05）.The incidence rate of adverse reactions had no obvious difference between the two groups （83.3% vs 66.7%,χ2 =2.88, P 〉0.05）.Conclusion Drug combination therapy in the treatment of unstable type of coronary heart disease angina pectoris can synergistically improve clinical symptoms and physical fitness,improve patients＇quality of life,it is safe and reliable,which is worth popularization and application widely.
出处
《中国基层医药》
CAS
2016年第14期2145-2148,共4页
Chinese Journal of Primary Medicine and Pharmacy
关键词
冠心病
心绞痛
阿司匹林肠溶片
氯吡格雷
疗效
Coronary heart disease
Angina pectoris
Enteric -coated aspirin
Clopidogrel
Cura-tive effect
