摘要
目的：探讨早期肠内营养对直肠癌患者术后康复的影响。方法选取2012年6月至2014年3月本院收治的直肠癌患者78例为研究对象，按随机数字表法分为A、B两组，每组39例，两组患者均接受外科手术治疗。B组术后予以常规营养干预方案，A组术后予以早期肠内营养干预方案。记录两组患者术后首次肛门排气时间、首次排便时间、总住院时间、营养费用和治疗总费用，记录术前（T0）、术后5 d（T1）、术后10 d（T2）等时点血清血红蛋白（HB）、转铁蛋白（TF）、白蛋白（ALB）、白细胞介素6（IL-6）和肿瘤坏死因子α（TNF-α）水平，比较两组患者切口愈合情况和术后并发症发生情况。结果 A组患者术后首次肛门排气时间、首次排便时间和总住院时间均显著低于B组（均P〈0.05），营养费用则显著高于B组（P〈0.05），而两组患者治疗总费用差异无统计学意义（P〉0.05）。A组患者T1、T2时点血清TF水平与T0时点比较，差异无统计学意义（均P〉0.05）；而HB、ALB水平较T0时点均显著增加（均P〈0.05）。B组患者T1、T2时点血清TF水平较T0时点显著降低（均P〈0.05），而HB、ALB水平均较T0时点显著增加（均P〈0.05）。T1、T2时点A组患者血清HB、TF、ALB水平均显著高于B组（均P〈0.05）。T1、T2时点，B组患者血清TNF-α、IL-6等炎性因子水平均显著高于同组T0时点及同时点A组患者（均P〈0.05）。A组、B组患者切口甲级愈合率分别为94.9%（37/39）和92.3%（36/39），组间比较差异无统计学意义（P〉0.05）。两组患者术后并发症发生率差异无统计学意义（P〉0.05）。结论早期肠内营养应用于直肠癌患者的术后康复治疗中，可缩短术后康复时间，有利于改善患者营养状态和预后。
Objective To investigate the effect of early enteral nutrition on postoperative rehabilitation of patients with rectal cancer. Methods Seventy-eight patients with rectal cancer,who were hospitalized in our hospital between June 2012 and March 2014,were included as the subjects in the study and randomly divided into groups A and B（n=39 each）. All the patients received surgical treatment. After the operation,group B was treated with routine nutrition intervention,and group A was given early enteral nutrition intervention. The initial anal exhaust time and initial defecation time after operation,total hospital stay,nutrition expense,and total expense of treatment in the two groups were recorded. The serum hemoglobin（HB）,transferrin（TF）,albumin（ALB）,interleukin-6（IL-6）and tumor necrosis factor-α（TNF-α） levels at the baseline （T0）,5 d （T1） and 10 d （T2） after the operation were recorded. The condition of wound healing and the incidence of postoperative complications were compared between the two groups. Results The initial anal exhaust time and initial defecation time after the operation,and total hospital stays in group A were significantly lower than those in group B（all P〈0.05）,whereas the nutrition expense was significantly higher than that in group B （P〈0.05）. There was no statistically significant difference in the total expense of treatment between group A and group B（P〉0.05）. There was no statistically significant difference in the serum TF level at T1 and T2 compared with that at T0 in group A（both P〉0.05）;whereas the HB and ALB levels were significantly increased compared with those at T0（all P〈0.05）. The serum TF level at T1 and T2 were significantly decreased compared with that at T0 in group B（both P〈0.05）;whereas the HB and ALB levels were significantly increased compared with those at T0（all P〈0.05）. The serum HB,TF and ALB levels at T1 and T2 in group A were significantly higher than those in group B （all P〈0.05）. The serum TNF-αand IL-6 levels at T1 and T2 were significantly higher than those at T0 in group B and those at the same time points in group A（all P〈0.05）. The grade-A wound healing rate in groups A and B was 94.9%（37/39） and 92.3%（36/39）,respectively,and the difference was not statistically significant （P〉0.05）. There was no statistically significant difference in the postoperative complication between the two groups （P〉0.05）. Conclusion Early enteral nutrition may shorten the postoperative recovery time and improve the nutritional status and prognosis of patients with rectal cancer in postoperative rehabilitation.
出处
《中华生物医学工程杂志》
CAS
2016年第1期72-75,共4页
Chinese Journal of Biomedical Engineering
关键词
早期肠内营养
直肠肿瘤
康复
炎性因子
Early enteral nutrition
Rectal neoplasms
Rehabilitation
Inflammatory factors
