摘要
骨性关节炎(osteoarthritis,OA)的发生和发展离不开软骨和软骨下骨共同病变的过程。信号通路的异常在调控OA软骨下骨和软骨的病变中起重要作用。Wnt、转化生长因子β(transforming growth factorβ,TGFβ)/骨形态发生蛋白(bone morphogenetic protein,BMP)、丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)信号通路对骨和软骨正常生长发育和代谢有着重要的调控作用,维持了关节的健康和平衡。研究显示,在OA中,这些信号通路的改变不仅可使OA软骨下骨和软骨的细胞表型和分子功能失衡,细胞外基质的合成破坏,软骨下骨骨重塑,还可通过破坏组织细胞的代谢进一步改变骨和软骨的结构及应力承担能力。因此,本文围绕骨关节炎病变中Wnt、TGFβ/BMP、MAPK信号交流在OA中软骨下骨和软骨病变中的作用和机制进行综述,以期为OA和其他骨关节疾病的研究和治疗提供新的方法和思路。
The occurrence and development of osteoarthritis （OA） can not be separated from the common patho- logical changes of cartilage and subchondral bone. Abnormal signal pathway plays an important role in the regulation of bone and cartilage lesions in OA. Wnt, TGFβ （transforming growth factor β） /BMP （bone morphogenetic protein）, MAPK （mitogen-activated protein kinases） signaling pathway plays an important role in the normal growth and metabo- lism of bone and cartilage, maintaining the health and balance of the joints. Studies have shown that in the lesions of os- teoarthritis, these signals can not only make the cell phenotype and molecular function imbalance of OA subchondral bone and cartilage, the synthesis of extracellular matrix distroyed, subchondral bone remodeling, but also destrog the metabo- lism of tissue cells and further change the structure and bear ability of stress of bone and cartilage. Therefore, this review summarizes the role and mechanism of Wnt, TGF/BMP, MAPK signaling of OA on communication between cartilage and subchondral bone, in order to provide new methods and ideas for the research and study of osteoarthritis and other bone diseases.
出处
《中华骨质疏松和骨矿盐疾病杂志》
2016年第2期193-198,共6页
Chinese Journal Of Osteoporosis And Bone Mineral Research
基金
国家自然科学基金面上项目(81572218)
上海市自然科学基金(13ZR1439100)
上海市卫生局局级课题面上项目科研基金(20124303)
