摘要
肝切除、肝静脉血栓形成、肝动脉栓塞、肝移植、门静脉高压等各种情况下肝脏出现巨大的血流变化。为了降低门静脉高压导致的门静脉流量减少,肝动脉缓冲区做出反应以增加肝动脉流量。与增加的肝动脉流量相关的血流动力学压力促进巨噬细胞浸润,调节门静脉肌成纤维细胞功能,有助于门静脉高压下汇管区纤维化的发展。外泌体源性microRNAs参与了肝脏重塑的过程,它可能是一个潜在的治疗靶点。本文就肝脏血流动力学变化导致肝脏重塑的相关机制作一综述。
Dynamic blood flow changes occur in the liver in various conditions,such as liver resection,hepatic vein thrombosis,hepatic artery embolization,liver transplantation and portal hypertension.In portal hypertension,the hepatic arterial buffer response increases hepatic arterial flow in response to decreased portal venous flow in portal hypertension.Hemodynamic stresses associated with increased hepatic arterial flow promote infiltration of macrophages that modulate function of portal myofibroblast and contribute to the development of portal tract fibrosis in portal hypertension.Exosomes derived microRNAs are involved in mechanisms of liver remodeling,and hence they can be a potential therapeutic tool.The related mechanisms of hepatic hemodynamic changes in liver remodeling was reviewed in this paper.
出处
《武汉大学学报（医学版）》
CAS
2016年第4期651-654,658,共5页
Medical Journal of Wuhan University
