期刊文献+

氮卓斯汀滴眼液和富马酸依美斯汀滴眼液治疗过敏性结膜炎疗效比较 被引量:14

Efficacy of azelastine and emedastine in treatment of allergic conjunctivitis
在线阅读 下载PDF
导出
摘要 目的探讨氮卓斯汀滴眼液和富马酸依美斯汀滴眼液治疗过敏性结膜炎的临床疗效。方法回顾性分析2014年1月~2015年12月我院门诊收治的过敏性结膜炎患者112例,随机分成富马酸依美斯汀组和氮卓斯汀组,其中氮卓斯汀组50例,富马酸依美斯汀组62例,分别使用氮卓斯汀滴眼液和富马酸依美斯汀滴眼液点眼,并于用药前、用药后第3天和第7天询问患者症状并用裂隙灯进行眼前节检查,并对各观察项目进行评分及统计学处理,比较治疗前后眼部症状、眼部体征和临床疗效。结果用药后3d和7d,两组患者组内眼部临床症状和体征均明显改善,但两组患者疗效比较差异无统计学意义(P〉0.05)。结论氮卓斯汀滴眼液与富马酸依美斯汀滴眼液治疗过敏性结膜炎均安全有效。 Objective To investigate the clinical efficacy of azelastine and emedastine in treatment of allergic conjunctivitis. Methods Retrospectively analysed the clinical data' of 112 cases admitted to hospital from Jun 2014 to Dec 2015 in patients with allergic conjunctivitis. All cases were randomly divided into azelastine group and emedastine group. There were 50 cases in azelastine group and 62 cases in emedastine group. Azelastine eye drops and emedastine eye drops were used respectively, and before treatment, 3 days and 7 days after treatment, the patients were asked about symptoms and their eye anterior segment were checked with slit lamp,: and each observation score was projected and statistical analysis was performed, eye symptoms and signs and clinical efficacy were compared before and after treatment. Results Treatment efficacy was significant in 3 days and 7 days after treatment between the two groups, and the differences between the two groups were not statistically significant (P〉0.05). Conclusion Azelastine and emedastine of the applications are safe and effective.
出处 《中国现代医生》 2016年第14期100-102,共3页 China Modern Doctor
基金 广东省深圳市科技计划项目(JCYJ20130401114111455)
关键词 过敏性结膜炎 氮卓斯汀滴眼液 富马酸依美斯汀滴眼液 Allergic conjunctivitis Azelastine Emedastine
  • 相关文献

参考文献14

  • 1Berdy GJ. Ocular allergic disease in the senior patient: Diagnosis and management[J]. Allergy Asthma Proc, 2000, 21 (5) : 277-283.
  • 2Endre L. The prompt effect of emedastine eye drop and the safety of its permanent use in children suffering from a- cute seasonal allergic conjunctivitis[J]. Ow Hetil, 2007, 148(6) :251-254.
  • 3陈建宏.0.1%盐酸奥洛他定滴眼液治疗季节性变态反应性结膜炎疗效观察[J].中国药物与临床,2010,10(11):1289-1291. 被引量:9
  • 4刘祖国,肖启国.过敏性结膜炎的诊治[J].中华眼科杂志,2004,40(7):500-502. 被引量:64
  • 5Hong J,Zhong T, Li H, et al. Ambient air pollution weath- er changes,and outpatient visits for allergic conjunctivitis: A retrospective registry study[J]. Sci Rep,2016,1 (6) ; 23858.
  • 6Chen J,Zhang J,Zhao R,et al. Topical application of in- terleukin-28A attenuates allergic conjunctivitis in an oval- bumin-induced mouse model[J]. Invest Ophthalmol Vis Sci, 2016,57(2) :604-610.
  • 7Woodward DF,Hawley SB ,Williams LS,et al. Studies on the ocular pharm-acology of prostaglandin D2[J]. Invest Ophthalmol Vis Sci, 1990,31( 1 ):138-146.
  • 8Katelaris CH. Ocular allergy:Implications for the clinical immunologist[J]. Ann Allergy Asthma Immunol, 2003,90 (6):23-27.
  • 9Bielory L. Allergic and immunologic disorders of the eye. Part I:Immu-nology of the eye[J]. J Allergy Clin Immunol, 2000,106(5) : 805-816.
  • 10Giede C,Metzenauer P,Petzold U, et al. Comparison of azelastine eye drops with levocabastine eye drops in the treatment of seasonal allergic conjunctivis[J]. Curr Med Res Opin,2000,16(3) : 153-163.

二级参考文献35

  • 1Berdy GJ,Hedqvist B.Ocular allergic disorders and dry eye disease:associations,diagnostic dilemmas,and management.Acta Ophthalmol Seand,2000,230(Suppl):32-37.
  • 2Berdy GJ.The effects of systemic medication on ocular allergic disease.Acta Ophthalmologica,2000,78:26-31.
  • 3Enerback L,Pipkom UG,Granerus G.Intraepithelial migration of nasal mucoal mast cells in hayfever.Int Arch:Allergy Appl Immunol,1986,80:44-51.
  • 4Sharif N,Xu SX,Magnino P,et al.Human conjunctival cells express histaminel receptors coupled to phosphoinositide turnover and intracellular calcium mobilization:role in ocular allergic and inflammatory diseases.Exp Eye Res,1996,66:169-178.
  • 5Abelson MS,Schaefer K.Conjunctivitis of allergicotigin:immunoiogic mechanisms and current approaches to therapy.Surv Ophthalmol,1993,38(Suppl):115-132.
  • 6Jun J,Bielory L,Raizman MB.Vernal conjunctivitis,Immunol Allergy Clin North Am,2008,28(1):59-82.
  • 7Berdy GJ,Hedqvist B.Ocular allergic disorders and dry eye disease:associations,diagnostic dilemmas,and management.Acta Ophthalmol Scand Suppl 2000;(230):32-37.
  • 8James IG,Campbell LM,Harrison JM,et al.Comparison of the efficacy and tolerability of topically administered azelastine,sodium cromoglycate and placebo in the treatment of seasonal allergic conjunctivitis and rhinoconjuncvitis.Curr Med Res Opin 2003;19(4):313-320.
  • 9Endre L.The prompt effect of emedastine eye drop and the safety of its permanent use in children suffering from acute seasonal allergic conjunctivitis.Orv Hetil 2007;148(6):251-254.
  • 10Keane-Myers A. The pathogenesis of allergic conjunctivitis. Curr Allergy Asthma Rep, 2001,1:550-557.

共引文献77

同被引文献93

引证文献14

二级引证文献75

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部