摘要
目的研究血管生成抑制蛋白-1对Ig A肾病患者预后的影响。方法选择60例Ig A肾病患者参与此次前瞻性研究,ELISA法测定血浆血管生成抑制蛋白-1水平,患者定期随访,定义终点事件为终末期肾病(ESRD)或血肌酐(Scr)升高超过100%以上,定义生存时间为患者肾活检至终点事件的时间。结果 Kaplan-Meier生存分析显示:血浆血管生成抑制蛋白-1升高者,患者进入终点事件的风险明显高于低水平者(P=0.001)。结论血管生成抑制蛋白-1是预测Ig A肾病患者预后的独立危险因素。
Objective To explore the influence of angiogenesis inhibitor protein-1 on prognosis of Ig A nephropathy patients.Methods A total of 60 Ig A nephropathy patients were enrolled in the prospective study.The plasma angiogenesis inhibitor protein-1 level was conducted by ELISA.Patients were followed up at regular intervals.The end point event was designed as end-stage renal disease（ESRD） or over 100% enhancement of Scr.The survival time was defined as the time duration from renal biopsy to end point event.Results Kaplan-Meier survival analysis showed that the risk of end point event was significantly higher in patients with increased plasma angiogenesis inhibitor protein-1 level than those with lower level（P=0.001）.Conclusion Angiogenesis inhibitor protein-1 is an independent risk factor influencing the prognosis of Ig A nephropathy patients.
出处
《中国现代医生》
2016年第12期4-7,F0003,共5页
China Modern Doctor
基金
浙江省丽水市科技计划项目(2014ZC007)
关键词
血管生成抑制蛋白-1
IG
A肾病
生存分析
终末期肾病
Angiogenesis inhibitor protein-1
Ig A nephropathy
Survival analysis
End-stage renal disease
