摘要
目的:观察海芋对小鼠急性毒性反应。方法:取海芋茎汁给ICR小鼠高、低剂量灌胃给药,观察小鼠毒性反应,测定小鼠外周血常规,谷丙转氨酶(ALT)、谷草转氨酶(AST),并取小鼠口腔、胃、肝、肾做切片,观察病理变化。结果:灌胃给药后7 d,小鼠食欲减小,体重减轻,与空白对照组比较呈现极显著性差异(P<0.01),外周血常规白细胞数(WBC)值以及血液生化学指标ALT值均高于空白对照组,其口腔、胃黏膜、肝病理切片均有一定的病变。结论:海芋有一定的毒性,不能食用,误服后一定要及时医治。
Objective： To observe the effect of Alocasia macrorrhiza on acute toxicity in mice. Methods： ICR mice were administrated by high and low dose of Alocasia macrorrhiza stalk juice. The toxicity of mice was observed. The routine blood test,Alanine aminotransferase（ ALT） and aspartate aminotransferase（ AST） were measured. The pathological changes were observed by mouth,stomach,liver and kidney slices of the mice. Results： After injection,the appetite of the mice decreased and the weight loss. There was significant difference of the weight change between the medicine group and the blank control group（ P〈0. 05）. The peripheral blood routine of white blood cells（ WBC） value and blood biochemical indexes of ALT values were higher than the blank control group＇s. The mouth,gastric mucosa and liver sections of the mice had certain pathological changes. Conclusion： Alocasia macrorrhiza has certain toxicity and is inedible. If someone takes it by mistake,he should be given timely treatment.
出处
《中华中医药学刊》
CAS
北大核心
2016年第6期1508-1510,I0002,共4页
Chinese Archives of Traditional Chinese Medicine
关键词
海芋
急性毒性
小鼠
Alocasia macrorrhiza
acute toxicity
mice
