摘要
目的通过水迷宫数据的变化,探讨模拟脑电节律仪的低频电磁场对大鼠认知功能的影响。方法将60只正常SD大鼠分为4组:正常对照组(A组,置于相同的固定装置内不予以治疗),1 Hz干预组(B组)、10 Hz干预组(C组)和20 Hz干预组(D组)。经模拟脑电节律仪干预正常SD大鼠后,应用水迷宫进行空间探索实验和定位航行实验,记录大鼠游泳的全部时程:平均逃避潜伏期、游泳路程以及大鼠在原平台象限游泳时间及2 min内跨越原平台次数,并进行比较。结果平均逃避潜伏期、游泳路程、大鼠在原平台象限游泳时间及2min内跨越原平台次数四组之间比较差异无统计学意义(P>0.05),平均逃避潜伏期和游泳路程A、B、C三组干预后均较干预前有所下降,D组有轻度上升,但差异无统计学意义(P>0.05);2 min内跨越原平台次数A组干预后较干预前略有上升,B组、C组、D组略有下降,但差异无统计学意义(P>0.05);原平台象限游泳时间四组干预后均较干预前略有下降,但差异无统计学意义(P>0.05)。结论模拟脑电节律仪的低频电磁场对正常大鼠的认知功能无不良影响,可能有改善作用。
Objective To study and determine the effect on cognitive function in normal SD rats through detecting the changes of water maze data before and after the different irradiated treatment by the low frequency electromagnetic field which simulates EEG instrument. Methods Sixty rats were divided into four groups：normal control group （group A）, placed in the same fixtures 30 minutes a day without treatment. Other groups were treated by EEG instrument regulated through extremely low frequency （1 Hz, group B ）, low frequence （ 10 Hz, group C ） and high frequence （ 20 Hz, group D ） electromagnetic fields 30 minutes a day. The dates of the average escape latency in full-time course, the paths of swimming,the swimming time across the original platform quadrant in each group of rats and the frequency of crossing the original platform within 2 minutes were compared and analyzed, the navigation test and space exploration test were applied by using water maze. Results There were no significant differences among the four groups in the incubation period of escape, the swimming path, the times and numbers that crossed platform within 2 minutes （ P 〉 0. 05 ）. The incubation period of escape and the swimming path decreased after treatment in group A, group B and group C, while increased in group D, but there was no statistical difference （ P 〉 0. 05）. The numbers that crossed platform within 2 minutes increased after the treatment in group A, while slightly decreased in group B, group C and group D, but there was no statistical difference （ P 〉 0. 05 ）. The times that crossed platform within 2 minutes slightly decreased in four groups after the treatment. Conclusion There is no harmful effect of low frequency electromagnetic on normal rats and it may improve the cognitive function of rats.
出处
《中华脑科疾病与康复杂志（电子版）》
2016年第1期42-45,共4页
Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）
基金
全军医学科技青年培育项目(13QNP031)
关键词
低频电磁场
模拟脑电节律仪
水迷宫
认知功能
Electromagnetic fields
Simulative EEG instrument
Morris water maze
Cognitive function
