摘要
膜性肾病是成人肾病综合征常见的病因之一,发病率逐年升高。膜性肾病从本质上来说属于自身免疫性疾病,其公认机制为T淋巴细胞刺激B淋巴细胞的增殖和激活,导致免疫复合物形成并沉积于肾小球基底膜上皮细胞下。外周血淋巴细胞亚群为近年的研究热点,该文从T细胞亚群和B淋巴细胞两个方面阐述特发性膜性肾病免疫学研究的新进展,为其防治提供新的靶点。
Membranous nephropathy is one of the common causes of adult nephritic syndrome,and its incidence has been on the rise significantly. As a kind of autoimmune disease,membranous nephropathy is generally recognized to be caused by the deposition of immune complex formation under the glomerular basement membrane epithelium as a result of B lymphocyte proliferation and activation stimulated by T lymphocytes,but its specifical pathogenesis remains unclear. Peripheral blood lymphocyte subsets become a research hotspot in recent years. This paper aims to highlight the immunological research advances of T lymphocyte subsets and B lymphocytes in idiopathicmembranous nephropathy,so as to provide a novel target for the prevention and treatment of idiopathic membranous nephropathy.
出处
《中国临床新医学》
2016年第5期449-452,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
国家自然科学基金资助项目(编号:81260121)
关键词
特发性膜性肾病
免疫
T细胞亚群
B淋巴细胞
利妥昔单抗
Idiopathic membranous nephropathy（IMN）
Immunization
T lymphocyte subsets
B lymphocytes
Rituximab
