摘要
目的探究与分析重组人骨形态发生蛋白-2（rhBMP-2）结合纳米晶胶原基材料（nHAC）治疗腰椎不稳症的临床疗效及安全性。方法选取我院2013年3月至2014年5月收治的腰椎不稳症患者90例，采取随机数字表法分为以rhBMP-2结合nHAC治疗的实验组，单纯以nHAC治疗的对照组，每组各45例。对比两组患者JOA评价结果、术中出血量，术后3个月内感染率、肺部并发症发生率。结果实验组与对照组男性比例比较差异有统计学意义（46．67％与48．89％，χ2=0．03，P=0．84）。实验组与对照组优良率比较差异有统计学意义（93．33％与57．78％，χ2=5．49，P〈0．05）。实验组深静脉血栓发生率、感染发生率、肺部并发症发生率分别是4．44％、8．88％、6．67％，对照组分别是13．33％、24．44％、20．00％，两组比较差异均有统计学意义（χ2值分别为5．12、3．78、3．56，P均〈0．05）。结论rhBMP-2结合nHAC治疗腰椎不稳症的临床疗效较佳，并发症发生率较低，安全性相对高，相比于传统手术方法具有诸多优势，可作为一种理想方法应用于临床工作中。
Objective To explore and analyze clinical efficacy and safety of restructuring morphogenesis protein-2 bones（rhBMP-2） combined with nanocrystalline collagen bone material（nHAC） fusion between treating lumbar protrusion of the lumbar spine instability. Methods Ninety cases of patients with lumbar instability syndrome who were treated in the People＇s Hospital of Heze from March 2013 to May 2013 were selected and divided into restructure morphogenesis protein-2 combined with nanocrystalline bone collagenbone material treatment group, purely in nanoerystalline collagen bone material treatment of the control group according to the random number table method, 45 cases in each group. JOA evaluation results, intraoperative blood loss, postoperative infection, pulmonary complications within three months of the two groups were compared. Results The male proportion of experimental group and control group was 46. 67% and 48. 89% respectively, the difference was significant （χ2 = 0. 03, P = 0. 84） . The excellent rate of experimental group and control group was respectively 93.33%, 57. 78%, the difference was significant （ χ2 = 5.49, P〈 0.05 ） . The incidence of deep vein thrombosis, infection rate, incidence of pulmonary complications of experimental group were 4. 44% ,8. 88% ,6. 67% ,of control group were 13.33% ,24.44% ,20.00% ,the differences were significant （χ2=5.12,3.78,3.56;P〈0.05） . Conclusion Restructuring morphogenesis protein-2 bones combined with nanocrystalline collagen bone material treating lumbar fusion between the clinical curative effect of treating lumbar instability syndrome is better, with a lower incidence of complications, security is relatively high, compared to traditional surgery method has many advantages, can be used as a kind of ideal method used in the clinical work.
出处
《中国综合临床》
2016年第4期358-361,共4页
Clinical Medicine of China
关键词
重组人骨形态发生蛋白-2
纳米晶胶原基骨材料
腰椎不稳症
临床疗效
安全性
Restructuring morphogenesis protein-2 bones
M crystal collagen bone material
Lumbar spinal instability syndrome
Clinical curative effect
Security
