摘要
细菌耐药性一直是全球关注的焦点问题,随着世界范围内化学药抗生素的滥用和"超级细菌"的层出不穷,细菌耐药性对人类的危害愈发严重,且有不可抑制的趋势。在化学药抗生素相对匮乏的今天,人们把更多的目光投向了来源广泛、安全性高、毒副作用小、抗耐药机制神秘的中草药,希望能从中找到解决耐药性问题的新途径或新思路。故近年来筛选、提取、分离天然植物及中药中有效的耐药抑制剂,探讨其抗耐药性机制,已成为药学领域研究的热点。该文从细菌耐药性的作用机制,中药抗细菌耐药性的特点及优势,抗耐性的中药成分等几个方面进行了分析和总结,希望能为解决细菌耐药性问题和研发新型中药绿色抗生素提供一定的理论基础及研究思路。
Bacterial drug resistance has been always the focus of the world. With the abuse of antibiotics and the emerging of ＂ Superbug＂ in the world,the harm of drug resistance to human beings is more and more serious,with an uncontrollable trend. Today,with the relative lack of antibiotics,people pay more attention to Chinese herbal medicines with a wide range of sources,high security,less toxic side effects and mysterious anti-drug resistance mechanism,hoping to find new ways or new ideas to solve the problem of drug resistance. In recent years,the screening,extracting and isolating of effective drug resistance inhibitors from natural plants and traditional Chinese Medicine,as well as the investigation in mechanism of anti-drug resistance,have become a hot research in the field of medicine. In this paper,we would analyze and summarize the action mechanism of bacterial drug resistance,characteristics and advantages of anti-drug resistance of traditional Chinese medicine,as well as the herbal ingredients with anti-drug resistance effect,hoping to provide certain theoretical basis and research ideas for solving the problem of bacterial drug resistance and developing new green Chinese antibiotics.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2016年第5期813-817,共5页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81173565)
江西省自然科学基金项目(20142BAB205083)
江西省教育厅科学技术研究项目(GJJ13609)
江西省卫生计生委中医药科研计划项目(2015A049)
关键词
细菌
耐药性
中药
绿色抗生素
bacteria
drug resistance
traditional Chinese medicine
green antibiotics
