摘要
天然牛黄是中国传统名贵中药材,来源于牛的胆囊、胆管或肝管中干燥后的胆结石。为满足临床需要,近年来相继研制出了人工牛黄、体外培育牛黄等品种。牛黄中主要含有胆红素类、胆汁酸类、氨基酸类、无机元素类等成分,胆汁酸类是牛黄类药材中除胆红素外的第二大类活性成分,与牛黄的解热镇痛、抗炎、利胆保肝、降压和镇咳等药理作用有密切关系。本文就牛黄类药材及其制剂中胆汁酸类成分的药理作用和含量测定方法的研究进展进行了综述和总结,旨在为牛黄的深入研究和质量控制提供参考依据。
Nature Calculus Bovis is one of the precious traditional Chinese medicines,which is the dried gallstone in gallbladder,bile duct or hepatic duct. In order to meet the clinical needs,we have developed artificial Calculus Bovis,in-vitro and other varieties. Calculus Bovis mainly contains bile pigments,bile acids,amino acids,inorganic elements and other types of components.Besides bile pigments,bile acids is the second largest of the active ingredients of Calculus Bovis,which is closely related to the antipyretic and analgesic,antiinflammatory effect and depressurization. The article outlines and summarizes the study progress in pharmacological effects and quantitative methods for components of bile acids in Calculus Bovis and its substitutes and preparations,aiming to provide a reference for subsequent research as well as quality control.
出处
《国际药学研究杂志》
CAS
CSCD
北大核心
2016年第2期268-274,共7页
Journal of International Pharmaceutical Research
基金
国家自然科学基金资助项目(81473347)
国家科技部"十二五"重大专项资助项目(2012ZX0934-005)
上海市科学技术委员会"含矿物药类中成药中人工牛黄不合理替代品种的纠正与标准制定"(15DZ0502700)
关键词
牛黄
胆汁酸
药理作用
定量分析方法
Calculus Bovis
bile acids
pharmacological actions
quantitative methods
