摘要
APOBEC3B是APOBEC3家族成员之一,是细胞内抗反转录病毒和反转录转座子的抑制因子。APOBEC3B利用其胞嘧啶脱氨酶活性,使病毒c DNA上的C脱氨基成U,导致另一条链生成A,产生G→A超突变。正常细胞发生大量的突变会诱发癌症。近期的研究显示在乳腺癌、宫颈癌、膀胱癌、肺癌、卵巢癌等肿瘤组织,APOBEC3B是被上调的,APOBEC3B被认为是造成人类多种癌症基因组U损伤和突变的重要来源。本文综述了APOBEC3B在抑制反转录病毒及癌症发展中的作用,为进一步研究抗病毒治疗和癌症的免疫治疗带来希望。
APOBEC3B is one member of APOBEC which inhibit retroviruses and retrotransposons.APOBEC3 B can deaminate cytidine to uridine in the minus strand DNA during reverse transcription and then leadinto the G to A hypermutation in the plus strand DNA. A large proportion of mutations in normal cells can causecancers. The latest studies indicate that APOBEC3 B is upregulated in breast, cervix, bladder, lung, ovary and othertumor tissues, so APOBEC3 B is identified as the likely source of genomic uridines damages and mutations inmultiple human cancers. This review illustrates the antiretroviral activities of APOBEC3 B and the role in carcinomadevelopment, and provides hopes for the antiviral therapy and cancer immune therapy.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2016年第5期453-456,共4页
Immunological Journal
