摘要
以L-色氨酸为起始原料,经过Pictet-Spengler缩合、氧化、烷基化反应、酰化反应合成了4个新型的双酰基取代的β-咔啉衍生物。采用MTT法考察其对肿瘤细胞的抑制作用,初步抗肿瘤活性测试结果表明,部分化合物表现出一定的抗肿瘤活性。
The starting material L-tryptophan reacted with aldehyde via Pictet-Spengler condensation, oxidation and decarboxylation, N9-alkylation and acylation reaction. Four novel 6,9-disubstituted-β-carboline derivatives were synthesized. The antitumor activity of the target compounds was studied by MTT method. The preliminary bioassay showed that some compounds possessed certain cytotoxic activities in vitro.
出处
《广东化工》
CAS
2016年第7期72-73,共2页
Guangdong Chemical Industry
基金
兵团中青年科技创新领军人才计划项目"2015BC001"
关键词
β-咔啉
合成
抗肿瘤活性
构效关系
β-carboline
synthesis
antitumor activity
structure-activity relationships
