摘要
目的探讨不同类的降压药物和不同钙拮抗剂对慢性脑血管病患者中血压变异性的影响。方法入选373例有慢性脑血管病的高血压患者,分别给予钙拮抗剂(CCBs)、(受体阻断剂(BBs)、血管紧张素转换酶抑制剂(ACEIs)和血管紧张素Ⅱ受体拮抗剂(ARBs)治疗后,行24h动态血压计算血压变异性,并进行统计分析。结果 BBs的日间血压变异性明显高于ARB或CCB(P<0.05),相比于其他CCB药物,西尼地平的日间血压变异性最低。结论 ARB和CCB相比于BBs更有利于脑血管疾病患者的高血压管理和治疗。而CCB中,由于较小的血压变异性,优选西尼地平。
Objective To explore the effects of 4 classes of anti-hypertensives on the blood pressure variability; in addition,the effects of 4 calcium channel blockers were also compared. Methods 24-hour blood pressure variability in 373 patients with a history of cerebrovascular disease was measured,they were treated with angiotensin-converting enzyme inhibitor,angiotensin receptor blocker,（ blocker,or calcium channel blocker. Results The daytime blood pressure variability treated with（ blockers was higher than that treated with angiotensin receptor blockers or calcium channel blockers in patients with cerebrovascular disease（ P 0. 05）.The blood pressure variability was the lowest in the group treated with cilnidipine in daytime. The mean blood pressure of patients grouped by distribution of blood pressure variability was found to be independent to blood pressure variability,for any of the antihypertensive drugs or calcium channel blockers examined. Conclusion From the results,it is suggested that angiotensin receptor blockers and calcium channel blockers rather than（ blockers might be more favorable for blood pressure management in patients with cerebrovascular disease. Among the calcium channel blockers,cilnidipine may be more favorable than other calcium channel blockers.
出处
《公共卫生与预防医学》
2016年第2期46-48,共3页
Journal of Public Health and Preventive Medicine
关键词
高血压
血压变异性
脑血管疾病
抗高血压药物
Hypertension
Blood pressure variability
Cerebrovascular disease（CVD）
Antihypertensive drugs
