摘要
胎盘早剥是是妊娠晚期的严重并发症之一,处理不当可危及母儿生命。胎盘的缺血性损伤被认为是胎盘早剥的最初原因。胎盘缺血性损伤导致了滋养细胞侵袭能力的改变及子宫螺旋小动脉发生的重塑障碍,胎盘缺血、缺氧后释放各种细胞因子造成蜕膜坏死、血管破裂、出血,而出血导致底蜕膜和胎盘之间形成撕裂和分离,进而造成蜕膜板和胎盘的分离。进一步造成更多的血管破裂、动脉出血和胎盘后血肿,最后导致胎盘早剥的发生。
Placental abruption is one of the most im- portant causes of maternal morbidity and perinatal mortality. The initial event leading to placental ab- ruption is thought to be an ischemic lesion of the de- cidua, resulting in decidual necrosis, vascular dis- ruption and bleeding. In the event of hemorrhage, laceration and dissection along a decidual plane and placental separation occur. The latter produces more vascular disruption, arterial hemorrhage and retro- placental accumulation of blood, which leads to pla- cental abruption at last.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2016年第4期312-315,共4页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
螺旋动脉
滋养细胞
氧化应激
spiral artery
trophoblast
oxidative stress
