摘要
目的:观察丹参类静脉制剂对择期PCI围手术期心肌损伤的保护作用。方法:非同期对照观察常规治疗及加用丹参粉针、丹参酮ⅡA注射液、丹红注射液,对择期PCI的不稳定心绞痛(Unstable Angina,UA)患者血清心肌标志物肌酸激酶同工酶(Myocardial-bound Creatine Kinase,CK-MB)的影响,探讨丹参类制剂对择期PCI围手术期的心肌保护作用。结果:PCI术后与术前相比较,常规组术后血清中CK-MB水平升高,差异有统计学意义(P<0.05);丹粉组术后血清中CKMB水平较术前亦有升高,差异无统计学意义(P>0.05);丹酮组术后血清中CK-MB水平较术前有所降低,其差异接近统计学意义(P=0.053);丹红组术后血清中CK-MB水平较术前有所降低,差异有统计学意义(P=0.033)。结论:丹参类静脉制剂对择期PCI围手术期心肌损伤的具有一定的保护作用,以丹红注射液作用最为明确。
Objective： To observe the effect of salvia miltiorrhiza intravenous preparations on selective PCI perioperative myocardial injury. Methods： To observe the effect of routine treatment combined with salvia miltiorrhiza powder injection,tanshinoneⅡA injection,Danhong injection respectively on serum myocardial markers Myocardial-bound Creatine Kinase（ CK-MB） in the serum of patients with unstable Angina（ UA） after selective PCI. Then discuss its protective mechanism on perioperative myocardium.Results： Compared with before treatment,the CK-MB level in the routine treatment group had increased with statistically difference（ P〈0. 05）. CK-MB level in the salvia miltiorrhiza group also increased with no statistical difference（ P〈0. 05）. CK-MB level in Tanshinone group decreased（ P = 0. 053）,and that of Danhong group also decreased（ P = 0. 033）. Conclusion： Salvia miltiorrhiza intravenous preparation,especially Danhong injection,has certain effect on PCI perioperative myocardial injury.
出处
《世界中医药》
CAS
2016年第3期384-387,共4页
World Chinese Medicine
基金
国家自然科学基金项目(编号:81273741)
国家中医药管理局重点学科基金
北京市215人才基金
北京市十百千人才基金
关键词
丹参
静脉制剂
PCI围手术期心肌损伤
Salvia miltiorrhiza
Intravenous agents
PCI perioperative myocardial injury
