摘要
背景:周围神经发生损伤后感觉、运动功能的恢复比较缓慢,且很少能够完全恢复感觉、运动功能,这一问题是困扰骨外科医师的难题,也是导致患者生活质量下降的主要原因。目的:分析周围神经损伤再生修复的新的治疗手段,总结前人在促进周围神经损伤再生方面采用的方法及取得的效果。方法:通过PubM ed、万方、中国知网数据库查阅关键词"神经损伤""再生"检索相关文献,整理分析数据。结果与结论:国内外学者针对周围神经损伤的再生,从手术方式、药物、细胞因子、基因转移、生物材料的应用及祖国医学的应用等多方面开展了研究。一般缺损大于神经直径的4倍,通常应用神经再生室取得了很好的效果。神经损伤后恢复神经连续性的方法由最初的手术吻合发展到现代的光化学组织结合、热激光焊接、胶修复等新兴技术。研究发现,纤溶酶原激活物、神经生长因子、神经营养因子、重组促红细胞生成素、人组织激肽释放酶、维生素B族及其衍生物、中药制剂、免疫抑制剂等在神经损伤修复的研究中均有促进神经再生修复的作用。
BACKGROUND： Recovery of motor and sensory function from peripheral nerve injury is relatively slow and incomplete. It is a difficult problem for orthopedic surgeons that mainly leads to the decline in the quality of life in patients. OBJECTIVE： To conclude the methods and corresponding outcomes in peripheral nerve regeneration by analyzing the new treatment means for peripheral nerve injury. METHODS： Pub Med, Wanfang, CNKI databases were retrieved for relevant articles using key words of ＂nerve injury, regeneration＂, and then retrieval data were sorted and analyzed. RESULTS AND CONCLUSION： In recent years, in-depth studies on peripheral nerve repair have been made in the following aspects： surgical mode, drug, cytokine, gene transfer and biomaterials as well as traditional Chinese medicine. If the detect size is four times longer than the diameter of nerves, the nerve regeneration chamber can achieve good outcomes. The methods of restoring nerve continuity following nerve injury are developed from surgical anastomosis to photochemohistological method, thermal laser welding, plastic repair and other emerging technologies. Studies have found that plasminogen activator, nerve growth factor, neurotrophic factor, recombinant erythropoietin, human tissue kallikrein, B vitamins and their derivatives, herbal preparations, immunosuppressive agents all can promote nerve regeneration.
出处
《中国组织工程研究》
CAS
北大核心
2016年第7期1044-1050,共7页
Chinese Journal of Tissue Engineering Research
基金
河北省卫生厅指令性课题(20130027)
河北省科技厅指令性课题(142777105D)
河北省承德市科技局课题(20123128)~~
