摘要
以离子液体苯丙酮吡啶六氟磷酸盐（[PaPy]PF6）作为修饰剂与膨胀石墨粉混合,成功制备出离子液体修饰膨胀石墨碳糊电极（IL-EGPE）。在pH=6.86 PBS缓冲溶液条件下,采用线性扫描溶出伏安法（LSSV）研究2,6-二甲基苯胺（DMA）在IL-EGPE上的电化学行为,建立利多卡因注射剂中杂质含量分析的新方法。实验结果表明,DMA在0.700 V附近出现一个很明显的还原峰,在一定浓度范围内,峰电流与DMA的浓度呈良好的线性关系,其线性范围为1.6×10^-6-1.52×10^-5mol/L,相关系数r=0.9994,回收率为95.6%-106.3%;该法操作简便、灵敏,可用于测定盐酸利多卡因注射液中的杂质2,6-二甲基苯胺的含量。
A Ionic liquid modified expanded graphite paste electrode（IL-EGPE） was constructed by blending propiophenone hexafluorophosphate（[PaPy]PF6） and expanded graphite. Linear sweep stripping voltammetry（LSSV）was used to record the electrochemical behavior of 2,6-methyltoluidine（DMA） in pH =6.86 PBS buffer solution. This method might be a new approach for determination of impurity in lidocaine hydrochloride injection. The results showed that DMA exhibited a reduction peak at 0.700 V. The increase of current intensity was proportional to DMA concentration in a linear range of 1.6×10^-6to 1.52×10^-5mol/L with correlation coefficient r = 0.9994. This simple and sensitive method was also applied to detect concentration of DMA in lidocaine hydrochloride injection solution.
出处
《化学传感器》
CAS
2015年第4期55-59,共5页
Chemical Sensors
基金
国家级大学生创新创业训练计划项目（201510399013）
福建省教育厅基金（JA13265）
关键词
离子液体
膨胀石墨
碳糊电极
线性溶出伏安法
2
6-二甲基苯胺
ionic liquids
expanded graphite
carbon paste electrode
linear sweep stripping voltammetry
2
6-methyltoluidine
