摘要
人体必需微量元素硒具有多种生物学活性,这依赖于硒摄入的水平。相对较低的硒摄入决定含硒酶的表达,含硒酶是人体质量主要的组份。较高水平的硒摄入已被证明具有抗肿瘤的潜能,而非常高的硒摄入可对机体产生不良影响。这种生物活性的层次性要求不同水平的硒暴露有不同的生物标志物信息。一些硒的生物标志物,如硒蛋白,特别是GPX3和SEPP1,可直接提供功能相关的信息,并在识别营养性硒缺乏及追踪硒缺乏个体补硒治疗疗效方面有重要价值。它们在硒摄入情况下可有效的调节范围内硒蛋白的表达。其他硒生物标志物通过基于食品、组织、尿液或粪便中硒含量的推论间接的提供信息。它们可以提示硒缺乏或不良反应的可能性,却不能提供其直接证据。它们的价值在于提供广泛的硒摄入量的硒状态信息,特别是来自食物形式的。
The essential trace element,selenium（Se）,has multiple biological activities,which depend on the level of Se intake.Relatively low Se intakes determine the expression of selenoenzymes in which it serves as an essential constituent.Higher intakes have been shown to have anti-tumorigenic potential;and very high Se intakes can produce adverse effects.This hierarchy of biological activities calls for biomarkers informative at different levels of Se exposure.Some Se-biomarkers,such as the selenoproteins and particularly GPX3 and SEPP1,provide information about function directly and are of value in identifying nutritional Se deficiency and tracking responses of deficient individuals to Se-treatment.They are useful under conditions of Se intake within the range of regulated selenoprotein expression.Other Se-biomarkers provide information indirectly through inferences based on Se levels of foods,tissues,urine or feces.They can indicate the likelihood of deficiency or adverse effects,but they do not provide direct evidence of either condition.Their value is in providing information about Se status over a wide range of Se intake,particularly from food forms.
出处
《国外医学（医学地理分册）》
CAS
2016年第1期44-48,共5页
Foreign Medical Sciences：Section of Medgeography
基金
国家自然科学基金资助项目(No.81472924)
2015年陕西省卫生和计划委员会大骨节病综合防治项目
关键词
硒
生物标志物
硒代蛋氨酸
硒代半胱氨酸
selenium
biomarkers
selenomethionine（SeMet）
selenocysteine（SeCys）
