摘要
目的探讨海昆肾喜胶囊联合阿魏酸钠治疗慢性肾衰竭的临床疗效。方法选取2012年5月—2015年5月彭州市中医医院收治的慢性肾衰竭患者120例,随机分为对照组和治疗组,每组各60例。对照组静脉滴注注射用阿魏酸钠,0.3 g加入到5%葡萄糖注射液200 m L中,1次/d。治疗组在对照组的基础上口服海昆肾喜胶囊,2粒/次,3次/d。两组均连续治疗4周。观察两组的临床疗效,同时比较两组治疗前后血清尿素氮、血肌酐、内生肌酐清除率及尿蛋白的变化情况。结果治疗后,对照组和治疗组的总有效率分别为71.67%、81.67%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清尿素氮、血肌酐、尿蛋白均显著降低,内生肌酐清除率显著升高,同组治疗前后差异具有统计学意义(P<0.05);治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论海昆肾喜胶囊联合阿魏酸钠治疗慢性肾衰竭具有较好的临床疗效,可降低患者血清尿素氮、血肌酐及尿蛋白,提高内生肌酐清除率,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Haikun Shenxi Capsules combined with sodium ferulate in treatment of chronic renal failure. Methods Patients（120 cases） with chronic renal failure in Pengzhou Hospital of Traditional Chinese Medicine from May 2012 to May 2015 were randomly divided into control（n = 60） and treatment（n = 60） groups. The patients in the control group were iv administered with Sodium Ferulate for injection, 0.3 g add into 5% glucose injection 200 mL, once daily. The patients in the treatment group were po administered with Haikun Shenxi Capsules on the basis of the control group, 2 grains/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacy was evaluated, and the changes of serum urea nitrogen, serum creatinine, endogenous creatinine clearance and urinary protein in two groups before and after treatment were compared. Results After treatment, the efficacies in the control and treatment groups were 71.67% and 81.67%, respectively, and there were differences between two groups（P〈0.05）. After treatment, serum urea nitrogen, serum creatinine, and urine protein were significantly decreased, and endogenous creatinine clearance were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Haikun Shenxi Capsules combined with sodium ferulate has clinical curative effect in treatment of chronic renal failure, and can reduce serum urea nitrogen, serum creatinine and urinary protein, also can improve the endogenous creatinine clearance, which has a certain clinical application value.
出处
《现代药物与临床》
CAS
2016年第3期350-353,共4页
Drugs & Clinic
关键词
海昆肾喜胶囊
注射用阿魏酸钠
慢性肾衰竭
Haikun Shenxi Capsules
Sodium Ferulate for Injection
chronic renal failure
