摘要
目的探讨幽门螺杆菌（Helicobacter pylori,Hp）药敏试验对临床根除治疗Hp感染及消化性溃疡的价值。方法选取在2013年2月~2014年10月山西省晋城市泽州县人民医院消化内科门诊诊治及住院患者120例（指导组）,其中胃溃疡69例、十二指肠球部溃疡患者51例,取患者病变黏膜组织进行Hp培养,对培养到的Hp菌株采用纸片琼脂扩散法进行抗生素药敏试验并根据药敏试验指导用药,另选120例消化性溃疡患者作为常规组,观察2组溃疡治疗效果及Hp根除效果的差异。结果指导组120例患者有75例患者成功培养出Hp,进行药敏试验结果为：对庆大霉素最敏感（94.67%）、呋喃唑酮次之（88.00%）、对甲硝唑敏感性最低（8.00%）;治疗结束4周后复查,指导组患者的溃疡愈合率93.33%显著的高于常规组的溃疡愈合率81.67%,指导组患者的腹痛缓解时间（3.5±1.5）d显著的短于常规组患者的（4.3±1.7）d;指导组患者的Hp根除率为89.17%显著的高于常规组患者的78.33%且差异具有统计学意义（P〈0.05）。结论根据Hp药敏试验,临床可以选择Hp敏感的抗菌药物结合质子泵抑制剂＋阿莫西林进行治疗,能取得更显著的临床效果。
Objective To explore the value of Helicobacter pylori（ Hp） drug sensitivity test for clinical treatment of Hp infection and peptic ulcer.Methods Selected from February 2013 to October 2014 gastroenterology clinic in the hospital inpatient treatment and 120 patients（ Steering Group）,of which 69 cases of gastric ulcer,duodenal ulcer 51 patients,mucosal lesions in patients took tissue culture Hp,Hp strain cultured to antibiotic susceptibility testing by disk diffusion method and based on susceptibility testing to guide treatment,alternative 120 cases of peptic ulcer patients as a routine group,ulcer treatment effect was observed between two groups and Hp eradication therapy. Results Steering group of 120 patients,75 patients were successfully cultured Hp,susceptibility test results： the most sensitive to gentamicin（ 94. 67%）,followed furazolidone（ 88. 00%）,the lowest sensitivity to metronidazole（ 8. 00 %）; reviewed 4 weeks after treatment,ulcer healing rate of steering group of patients 93. 33% was significantly higher than the end of treatment 4 weeks after the ulcer healing rate of regular group of 81. 67%,steering group of patients with abdominal pain short time（ 3. 5 ± 1. 5） d was significantly shorter than conventional group of patients（ 4. 3 ± 1. 7） d; Hp eradication of steering group patients was 89. 17%significantly higher than conventional group were 78. 33% and the difference was statistically significant（ P〈0. 05）. Conclusion According Hp susceptibility testing,can choose Hp sensitive proton pump inhibitor combination of antibiotics amoxicillin treatment,can achieve more significant clinical effect.
出处
《中国生化药物杂志》
CAS
2015年第11期107-109,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
幽门螺杆菌
药敏试验
根除治疗
消化性溃疡
Helicobacter pylori
susceptibility test
eradication therapy
peptic ulcer
