摘要
目的探讨小儿先天性肾积水血清胱抑素C（Cys C）、β2-微球蛋白（β2-MG）及α1-微球蛋白（α1-MG）含量及临床意义。方法选取2014年2月-2015年7月我院收治96例先天性肾积水患儿作为研究组,所有患儿均行手术治疗,术前根据患儿病情严重程度分为轻度组、中度组和重度组,并根据患儿是否行手术分为术前组和术后组,选取同期我院体检中心体检健康儿童60例作为对照组,比较各组血清Cys C、β2-MG、α1-MG含量水平。结果研究组患儿血清Cys C、β2-MG、α1-MG水平均高于对照组[（1.02±0.31）mg/L比（0.81±0.16）mg/L,（3.83±0.93）mg/L比（1.95±0.42）mg/L,（25.21±5.26）mg/L比（20.11±4.12）mg/L,P〈0.05]。轻度组、中度组、重度组患儿血清Cys C、β2-MG、α1-MG水平依次升高,组间比较差异有统计学意义（P〈0.05）。术后组血清Cys C、β2-MG、α1-MG水平显著低于术前组[（0.86±0.19）mg/L比（1.02±0.31）mg/L,（2.02±0.45）mg/L比（3.83±0.93）mg/L,（22.52±4.54）mg/L比（25.21±5.26）mg/L,P〈0.05]。结论先天性肾积水患儿血清Cys C、β2-MG、α1-MG水平显著升高,且与病情严重程度呈正相关,手术治疗后可显著降低血清Cys C、β2-MG、α1-MG水平,可作为辅助诊断、评定肾积水及严重程度有效临床指标。
Objective To study the content level and clinical significance of serum cystatin C（Cys C）,β2-microglobulin（β2-MG）,α1-microglobulin（α1-MG） in children with congenital hydronephrosis. Methods 96 children with congenital hydronephrosis,who were received and surgical treated in our hospital from Februry 2014 to July 2015,were selected as the study group,were divided into mild group,moderate group,and severe group according to the severity of children disease,and were divided into preoperative group and postoperative group according to whether received surgical or not.Another 60 healthy children,who were carried out physical examination in medical examination center of our hospital at the same time,were selected as the control group.To compare the content level of serum Cys C,β2-MG,α1-MG between the two groups. Results The content level of serum Cys C,β2-MG,α1-MG in study group[（1.02±0.31）mg/L,（3.83±0.93）mg/L,（25.21±5.26）mg/L] were higher than which in control group[（0.81±0.16）mg/L,（1.95±0.42）mg/L,（20.11±4.12）mg/L],which in mild group, moderate group,and severe group had increased orderly,and which in preoperative group[（0.86±0.19）mg/L,（2.02±0.45）mg/L,（22.52±4.54）mg/L] was significantly lower than which in postoperative group[（1.02±0.31）mg/L,（3.83±0.93）mg/L,（25.21±5.26）mg/L], the differences was statically significant（P〈0.05）. Conclusion The content level of serum Cys C,β2-MG,α1-MG in children with congenital hydronephrosis has obviously increased,is positive correlation with the severity of disease,could be significantly reduced after surgical treatment,could be the effective clinical idex on the aided diagnosis,the judgment on the hydronephrosis and severity condition.
出处
《中国医药科学》
2016年第1期155-157,共3页
China Medicine And Pharmacy
基金
广东省东莞市科技计划项目(201410515000130)
