摘要
目的：研究近视患者近视发病时间（T）对黄斑区脉络膜厚度（CT）的影响。方法：采用前瞻性队列研究方法。纳入2014-03/2015-04间在我院屈光手术中心行手术前检查的122例244眼近视患者。其中,男67例,女55例。年龄30~41（平均35.1±4.6）岁。根据发病时间分成3组：A组（T≤5a）、B组（5a0.05）、年龄（F=2.13,P〉0.05）、最佳矫正视力（F=1.41,P〉0.05）、角膜曲率（F=1.65,P〉0.05）、眼轴长度（F=1.89,P〉0.05）差异均无统计学意义。受检查者黄斑区脉络膜使用频域光相干断层扫描（SD-OCT）的深度增强成像（EDI）技术进行扫描。测量中心凹下CT（SFCT）以及距中心凹1、3mm处上方（S）、下方（I）、颞侧（T）、鼻侧（N）4个方位的CT。备方位点分别标记为S_（1mm）、I_（1mm）、T_（1mm）、N_（1mm）、S_（3mm）、I_（3mm）、T_（3mm）、N_（3mm）。分析三组间脉络膜相同位点CT值的差异。结果：A、B、C组的平均SFCT值分别为238.32±57.95、230.58±67.21、221.63±62.37μm。A、B组间及B、C组间除N_（3mm）外（t_（A-B）=4.34、t_（B-C）=7.61,P〈0.05）,其余各位点的CT值差异均无统计学意义（P〉0.05）;A、C组间除T_（3mm）外（t=0.76,P〉0.05）,其余各位点的CT值差异均有统计学意义（P〈0.05）;三组间两两比较,N_（3mm）的CT值差异均有统计学意义（t_（A-B）=4.31、t_（B-C）=7.59、t_（A-C）=12.18,P〈0.05）。结论：随着近视发病时间的延长,近视患者的脉络膜厚度变薄鼻侧尤为明显。
AIM：To investigate the effect of onset time（T） for macula choroidal thickness（CT） in myopia patient.·METHODS：A prospective cohort study was designed.One hundred and twenty-two myopia patients（244 eyes;67 male and 55 female;aged 30~41 years,mean 35.1±4.6years old） who received preoperative examinations from March 2014 to April 2015 were recruited in this study.The patients were divided into three groups according to onset time（T）：group A（T ≤ 5a）,group B（5aT≤10a） and group C（10a T ≤15a）.There were no significant differences on equivalent power（F=1.56,P0.05）,age（F=2.13,P0.05）,best corrected visual acuity（BCVA,F=1.41,P0.05）,corneal curvature（F= 1.65,P0.05） and axial length（F= 1.89,P0.05） among the three groups.The choroid in macular region was measured by enhanced depth imaging（EDI） using spectral-domain optical coherence tomography（SD-OCT）.This study recorded the CT at subfoveal（SFCT）,1mm at temporal（T_（1mm））,nasal（N_（1mm））,superior（S_（1mm）） and inferior（l_（1mm）） to the fovea and 3mm temporal（T_（3mm））,nasal（N_（3mm））,superior（S_（3mm）） and inferior（l_（3mm）） to the fovea,respectively.The differences of CT at the same position among the three groups were analyzed.·RESULTS：The mean SFCT for group A,B,C were 238.32±57.95μm,230.58±67.21μm,221.63±62.37μm respectively in this study.The CT was found no significant difference in different locations except N_（3mm）（t_（A-B） = 4.34,P0.05）between group A and B.The CT was found no significant difference in different locations except N_（3mm）（t_（B-C） = 7.61,P0.05） between group B and C.The CT was found significant difference in different locations,except T_（3mm）（t=0.76,P0.05） between group A and C.Significant difference was found at N_（3mm）（t_（A-B）=4.31,t_（B-C） = 7.59,t_（A-C） =12.18;P0.05） among the three groups.·CONCLUSION：The choroidal thickness decreases as the myopia onset time is earlier,especially at nasal.
出处
《国际眼科杂志》
CAS
2016年第3期523-525,共3页
International Eye Science
基金
爱尔眼科医院集团2014年度科研项目(No.AF143D09)~~
关键词
脉络膜厚度
发病时间
近视眼
光学相干断层扫描
choroidal thickness
onset time
myopic subjects
optical coherence tomography
