摘要
内毒素是革兰阴性菌细胞壁中的特有成分,又称脂多糖(LPS)。肝脏既是清除细菌和内毒素的场所,又是最易受损的器官。肝损伤最初发生在肝血窦。主要介绍了LPS对Kupffer细胞、肝窦内皮细胞、肝血窦中氧化/抗氧化平衡及肝脏血流的影响。认为肝血窦在LPS所造成的肝损伤中的作用不容忽视,研究其对防治LPS致肝损伤有重要意义。
Endotoxin, which is also called lipopolysaccharide （LPS） , is a unique element of Gram -negative bacteria. Liver is the main site for removing bacteria and endotoxin. Meanwhile, it is also the most vulnerable organ. Liver injury initially occurs in the hepatic sinu- soids. This article mainly introduces the impact of LPS on Kupffer cells, hepatic sinusoidal endothelial cells, oxidant/antioxidant balance in the hepatic sinusoids, and liver blood flow. It is believed that the function of hepatic sinusoids in LPS - induced liver injury should not be ignored, and the hepatic sinusoids would play an important role in the prevention and treatment of LPS - induced liver injury.
出处
《临床肝胆病杂志》
CAS
2016年第1期182-184,共3页
Journal of Clinical Hepatology
基金
2014年西藏自治区科技厅自然科学基金项目
关键词
肝疾病
脂多糖类
枯否细胞
综述
liver diseases
lipopolysaccharides
kupffer cells
review
