摘要
目的探讨颅脑损伤患者血清神经元特异性烯醇化酶（NSE）及心肌酶的变化及临床意义。方法选择2014年5月~2015年5月在绵阳市第三人民医院（以下简称＂我院＂）治疗的颅脑损伤患者90例,按格拉斯哥昏迷指数（GCS）评分分为重度损伤组28例,中度损伤组28例,轻度损伤组34例;另选则同期在我院行健康体检者30例为对照组。观察颅脑损伤各组伤后1、3、7 d血清NSE、心肌酶谱水平变化情况;分析颅脑损伤患者血清NSE水平与心肌酶谱各指标关系。结果 1轻度损伤组、中度损伤组、重度损伤组患者伤后第1、3天血清NSE水平均明显高于对照组,差异均有统计学意义（P〈0.01或P〈0.05）。中度损伤组、重度损伤组患者血清NSE水平均明显高于对照组,差异有统计学意义（P〈0.01或P〈0.05）。2伤后第1天轻度损伤组、中度损伤组、重度损伤组患者心肌酶谱谷草转氨酶（AST）、肌酸磷酸激酶（CPK）、乳酸脱氢酶（LDH）、肌酸激酶同工酶（CKMB）水平均明显高于对照组同项目,差异有统计学意义（P〈0.01或P〈0.05）。伤后第3天,中度损伤组、重度损伤组患者心肌酶谱AST、CPK、LDH、CKMB水平均明显高于对照组,差异有统计学意义（P〈0.01或P〈0.05）;轻度损伤组CPK、LDH、CKMB水平均明显高于对照组,差异有统计学意义（P〈0.01或P〈0.05）。伤后第7天,重度损伤组患者CPK、CKMB水平高于对照组,差异有统计学意义（P〈0.05）。3颅脑损伤患者伤后血清NSE水平和心肌酶谱各指标水平相关（P〈0.01）,NSE与AST、CPK、LDH和CKMB呈正相关（r=0.688、0.722、0.509、0.731,P〈0.01）。结论颅脑损伤患者血清NSE及心肌酶谱动态反映患者的颅脑损伤及心脏病变程度,并指导临床给予积极的治疗。
Objective To discuss the change and clinical significance of neuron specific enolization enzyme（NSE） and the myocardial enzymes in patients with craniocerebral injury. Methods From May 2014 to May 2015, in the Third People＇s Hospital of Mianyang City（＂our hospital＂ for short）, 90 patients with craniocerebral injury in were selected and divided into three groups according to GCS grade, 28 cases were in severe injury group, 28 cases were in moderate injury group, 34 cases were in mild injury group; 30 cases of physical examination in our hospital at the same time were chose as control group. The change conditions of serum NSE and myocardial enzymes level on 1, 3, 7 days after injury in craniocerebral injury group were observed; the relationship was analyzed between serum NSE level and myocardial enzymes level in craniocerebral injury patients. Results 1The serum NSE level of mild injury group, moderate injury group, severe injury group 1, 3 days after the injury were all higher than those in control group, the differences were statistically significant（P〈0.05 or P〈0.01）. The serum NSE level in moderate damage, severe injury group were all higher than those in control group, the differences were statistically significant（P〈0.05 or P〈0.01）. 2The myocardial enzyme of AST, CPK, LDH, CKMB level in mild injury group, moderate injury group, severe injury group 1day after the injury were all higher than those in control group, the differences were statistically significant（P〈0.05 or P〈0.01）. The myocardial enzyme of AST, CPK, LDH, CKMB level in moderate injury group, severe injury group 3days after the injury were all higher than those in control group, the differences were statistically significant（P〈0.05 or P〈0.01）; the CPK, LDH, CKMB level in mild injury group 3 days after the injury were higher than those in control group, the differences were statistically significant（P〈0.05 or P〈0.01）. The CPK, CKMB level in severe injury group were higher than those in control group, the differences were statistically significant（P〈0.05）. 3The positive correlation relationship was found between serum NSE level and myocardial enzymes level in craniocerebral injury patients（P〈0.01）, the correlation index between NSE and AST, CPK, LDH, CKMB showed positive correlation（r = 0.688,0.722, 0.509, 0.731, P〈0.01）. Conclusion The serum NSE level and myocardial enzymes level can dynamically reflect the degree of pathological changes of craniocerebral injury and heart lesion, can help clinic to give the active treatment to patients.
出处
《中国医药导报》
CAS
2016年第5期79-82,共4页
China Medical Herald
关键词
颅脑损伤
神经元特异性烯醇化酶
心肌酶
Craniocerebral injury
Neuron specific enolization enzyme
Myocardial enzyme
