摘要
1例41岁男性患者胶质母细胞瘤切除术后出现癫痫，给予奥卡西平（初始剂量为0．3g,2次／d，后加至0．6g,2次／d）和丙戊酸钠（500mg、1次／d）口服，因癫痫控制不佳加用拉莫三嗪（25mg鼻饲、2次／d）。加用拉莫三嗪第17天因出现肺感染给予头孢曲松（2g静脉滴注、1次／d）。加用拉莫三嗪第19天，患者面颈部、胸背部、双上肢、腹部、双下肢依次出现鲜红色斑丘疹，部分融合成片，诊断为药疹。停用拉莫三嗪和头孢曲松，奥卡西平和丙戊酸钠继续应用，并给予地塞米松，葡萄糖酸钙、维生素c等治疗。5d后患者皮损好转，9d后皮疹消退。
A 41-year-old man with epilepsy after glioblastoma resection received oral oxcarbazepine （an initial dose of 0.3 g twice daily, which was increased to 0.6 g twice daily） and valproate sodium （500 mg, once daily）. Nasal feeding lamotrigine 25 mg twice daily was added to her regimen due to poor control of epileptic condition. On day 17 of lamotrigine therapy, an IV infusion of ceftriaxone 2 g once daily was given for pulmonary infection. On day 19 of lamotrigine therapy, the patient developed red maculopapular eruptions successively on the face, neck, chest, back, arms, abdomen and legs, some rashes fused into [amella. He was diagnosed drug eruptions. Lamotrigine and ceftriaxone were discontinued immediately. Oxearbazepine and valproate sodium were continued. He was given dexamethasone, calcium glueonate and vitamin C. Five days later, his skin lesions were improved. Nine days after lamotrigine withdrawal, the skin eruptions subsided.
出处
《药物不良反应杂志》
CSCD
2015年第6期471-472,共2页
Adverse Drug Reactions Journal
关键词
拉莫三嗪
丙戊酸
药疹
Lamotrigine
Valproic acid
Drug eruptions
